Evidence map›Paper›PMID 36838844›Full record

ArticleMolecules (Basel, Switzerland)2023

Functionalized Sulfur-Containing Heterocyclic Analogs Induce Sub-G1 Arrest and Apoptotic Cell Death of Laryngeal Carcinoma In Vitro.

B Haridevamuthu, Tamilvelan Manjunathan, Carlton Ranjith Wilson Alphonse, Rajendran Saravana Kumar, Sundaram Thanigaivel, Somasundaram Chandra Kishore, Vickram Sundaram, Pushparathinam Gopinath, Jesu Arockiaraj, Stefano Bellucci

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. 3 Biotech · 2025
    Review
  2. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

B HaridevamuthuDepartment of Biotechnology, College of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, Chennai 603203, Tamil Nadu, India.ORCID 0000-0003-4598-5993
Tamilvelan ManjunathanDepartment of Chemistry, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Chennai 603203, Tamil Nadu, India.
Carlton Ranjith Wilson AlphonseMolecular and Nanomedicine Research Unit, Centre for Nanoscience and Nanotechnology, Sathyabama Institute of Science and Technology, Chennai 600119, Tamil Nadu, India.ORCID 0000-0002-0402-6385
Rajendran Saravana KumarChemistry Division, School of Advanced Sciences, VIT University, Chennai Campus, Chennai 600127, Tamil Nadu, India.
Sundaram ThanigaivelDepartment of Biotechnology, College of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, Chennai 603203, Tamil Nadu, India.
Somasundaram Chandra KishoreDepartment of Biomedical Engineering, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Chennai 602105, Tamil Nadu, India.
Vickram SundaramDepartment of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Chennai 602105, Tamil Nadu, India.
Pushparathinam GopinathDepartment of Chemistry, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Chennai 603203, Tamil Nadu, India.
Jesu ArockiarajDepartment of Biotechnology, College of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, Chennai 603203, Tamil Nadu, India.ORCID 0000-0002-0240-7141
Stefano BellucciINFN-Laboratori Nazionali di Frascati, 00044 Frascati, Italy.ORCID 0000-0003-0326-6368

Funding

Science and Engineering Research Board SERB-SRG/2019/001133SRM Institute of Science and Technology SR/FST/CST266/2015(c)
6 · The paper itself

Abstract

In this study, we speculate that the hydroxyl-containing benzo[b]thiophene analogs, 1-(3-hydroxybenzo[b]thiophen-2-yl) ethanone (BP) and 1-(3-hydroxybenzo[b]thiophen-2-yl) propan-1-one hydrate (EP), might possess antiproliferative activity against cancer cells. Hydroxyl-containing BP and EP show selectivity towards laryngeal cancer cells (HEp2), with IC

Indexed as

Antineoplastic AgentsCarcinomaLaryngeal NeoplasmsAntioxidantsApoptosisCell Line, TumorCell ProliferationG1 PhaseHumansMolecular Docking SimulationAntineoplastic AgentsAntioxidantsanticancerapoptosisbenzo[b]thiophenelaryngeal cancerpharmacology

Identifiers

PMID36838844
PMCPMC9963856

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.