Evidence map›Paper›PMID 36838815›Full record

ArticleMolecules (Basel, Switzerland)2023

Potential Anti-Alzheimer Properties of Mogrosides in Vitamin B12-Deficient

Denia Cai Shi, Chunlin Long, Ella Vardeman, Edward J Kennelly, Michael A Lawton, Rong Di

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. High-Dose Deltamethrin Induces Developmental Toxicity inMolecules (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Denia Cai ShiNew Brunswick Graduate School, Rutgers University, New Brunswick, NJ 08901, USA.ORCID 0000-0002-2307-7102
Chunlin LongCollege of Life and Environmental Sciences, Minzu University of China, Beijing 100086, China.ORCID 0000-0002-6573-6049
Ella VardemanGraduate Center, City University of New York, 365 5th Ave, New York, NY 10016, USA.ORCID 0000-0002-4960-0723
Edward J KennellyGraduate Center, City University of New York, 365 5th Ave, New York, NY 10016, USA.
Michael A LawtonDepartment of Plant Biology and Pathology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA.
Rong DiDepartment of Plant Biology and Pathology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA.ORCID 0000-0003-4581-0077
Rutgers, The State University of New Jersey · USThe Graduate Center, CUNY · USMinzu University of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin B12 deficiency can lead to oxidative stress, which is known to be involved in neurodegenerative diseases such as Alzheimer's disease (AD). Mogrosides are plant-derived triterpene glycosides that exhibit anti-inflammatory and antioxidant activity in animal cell lines and mouse models. Since amyloid-β toxicity is known to cause oxidative stress and damage to brain cells, we hypothesized that mogrosides may have a protective effect against AD. In this study, we investigated the potential anti-AD effect of mogrosides in vitamin B12-deficient wild-type N2 and in transgenic CL2355

Indexed as

Alzheimer DiseaseCaenorhabditis elegans ProteinsAmyloid beta-PeptidesAnimalsAnimals, Genetically ModifiedAntioxidantsCaenorhabditis elegansMiceOxidative StressPlant ExtractsVitamin B 12Amyloid beta-PeptidesAntioxidantsCaenorhabditis elegans ProteinsPlant ExtractsVitamin B 12Alzheimer’s diseaseCaenorhabditis elegansmogrosidesvitamin B12 deficiency

Identifiers

PMID36838815
PMCPMC9961707
OpenAlexW4320919007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.