Evidence map›Paper›PMID 36838810›Full record

ArticleMolecules (Basel, Switzerland)2023

Solid-Phase Synthesis of the Bicyclic Peptide OL-CTOP Containing Two Disulfide Bridges, and an Assessment of Its In Vivo μ-Opioid Receptor Antagonism after Nasal Administration.

Ramanjaneyulu Rayala, Annika Tiller, Shahayra A Majumder, Heather M Stacy, Shainnel O Eans, Aleksandra Nedovic, Jay P McLaughlin, Predrag Cudic

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ramanjaneyulu RayalaDepartment of Chemistry and Biochemistry, Charles E. Schmidt College of Science, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, USA.
Annika TillerDepartment of Chemistry and Biochemistry, Charles E. Schmidt College of Science, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, USA.
Shahayra A MajumderDepartment of Pharmacodynamics, School of Pharmacy, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USA.
Heather M StacyDepartment of Pharmacodynamics, School of Pharmacy, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USA.
Shainnel O EansDepartment of Pharmacodynamics, School of Pharmacy, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USA.
Aleksandra NedovicDepartment of Chemistry and Biochemistry, Charles E. Schmidt College of Science, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, USA.
Jay P McLaughlinDepartment of Pharmacodynamics, School of Pharmacy, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USA.ORCID 0000-0001-9851-9342
Predrag CudicDepartment of Chemistry and Biochemistry, Charles E. Schmidt College of Science, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, USA.ORCID 0000-0002-5633-4275
Florida Atlantic University · USUniversity of Florida · US

Funding

Novel opioid peptides for nose to brain deliveryR21DA039722 · NIDA · FLORIDA ATLANTIC UNIVERSITY · PI CUDIC, PREDRAG · 2016 to 2017
$455k
NIDA NIH HHS R21 DA039722NIH HHS R21 DA039722
6 · The paper itself

Abstract

New strategies facilitate the design of cyclic peptides which can penetrate the brain. We have designed a bicyclic peptide, OL-CTOP, composed of the sequences of a selective μ-opioid receptor antagonist, CTOP (f-

Indexed as

Solid-Phase Synthesis TechniquesSomatostatinAdministration, IntranasalAnimalsMiceMorphinePeptidesReceptors, Opioid, muMorphinePeptidesReceptors, Opioid, muSomatostatinantagonismCTOPdisulfide bondintranasal deliverymorphineodorranalectinrespiratory depressionsolid-phase synthesistrypsinμ-opioid receptor

Identifiers

PMID36838810
PMCPMC9963138
OpenAlexW4320920820

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.