Evidence map›Paper›PMID 36838792›Full record

ArticleMolecules (Basel, Switzerland)2023

Virtual Screening of Hepatitis B Virus Pre-Genomic RNA as a Novel Therapeutic Target.

Lukasz T Olenginski, Wojciech K Kasprzak, Solomon K Attionu, Bruce A Shapiro, Theodore K Dayie

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Selective [9-Chembiochem : a European journal of chemical biology · 2025
    Article
  4. Article
  5. Embracing exascale computing in nucleic acid simulations.Current opinion in structural biology · 2024
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Lukasz T OlenginskiDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.
Wojciech K KasprzakBioinformatics and Computational Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
Solomon K AttionuDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.
Bruce A ShapiroRNA Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA.
Theodore K DayieDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.
University of Maryland, College Park · USFrederick National Laboratory for Cancer Research · USNational Cancer Institute · US

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
National Science Foundation 1808705NCI NIH HHS 75N91019D00024
6 · The paper itself

Abstract

The global burden imposed by hepatitis B virus (HBV) infection necessitates the discovery and design of novel antiviral drugs to complement existing treatments. One attractive and underexploited therapeutic target is ε, an ~85-nucleotide (nt)

Indexed as

Hepatitis BHepatitis B virusCarbamatesGenomicsHumansImidazolesPyrrolidinesRNA, ViralValineVirus ReplicationCarbamatesdaclatasvirImidazolesPyrrolidinesRNA, ViralValinedrug discoveryhepatitis B virusmolecular dynamicsRNAvirtual screening

Identifiers

PMID36838792
PMCPMC9963113
OpenAlexW4320921469

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.