Evidence map›Paper›PMID 36838725›Full record

ArticleMolecules (Basel, Switzerland)2023

NMR-Based Metabolite Profiling and the Application of STOCSY toward the Quality and Authentication Assessment of European EVOOs.

Stavros Beteinakis, Anastasia Papachristodoulou, Peter Kolb, Paul Rösch, Stephan Schwarzinger, Emmanuel Mikros, Maria Halabalaki

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stavros BeteinakisDivision of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771 Athens, Greece.ORCID 0000-0003-4937-0822
Anastasia PapachristodoulouDivision of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771 Athens, Greece.ORCID 0000-0001-7296-0922
Peter KolbNBNC-North Bavarian NMR Centre, University of Bayreuth, Universitätsstraße 30, 95447 Bayreuth, Germany.
Paul RöschNBNC-North Bavarian NMR Centre, University of Bayreuth, Universitätsstraße 30, 95447 Bayreuth, Germany.ORCID 0000-0003-3330-2446
Stephan SchwarzingerNBNC-North Bavarian NMR Centre, University of Bayreuth, Universitätsstraße 30, 95447 Bayreuth, Germany.
Emmanuel MikrosDivision of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771 Athens, Greece.ORCID 0000-0002-5984-5169
Maria HalabalakiDivision of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771 Athens, Greece.ORCID 0000-0001-5620-0165

Funding

European Regional Development Fund (ERDF) and Greek national funds through the Operational Program "Competitiveness, Entrepre-neurship and Innovation", under the call "RESEARCH - CREATE - INNOVATE" (project: Oliveheart) Τ1ΕΔΚ-02434
6 · The paper itself

Abstract

Extra virgin olive oil (EVOO) possesses a high-value rank in the food industry, thus making it a common target for adulteration. Hence, several methods have been essentially made available over the years. However, the issue of authentication remains unresolved with national and food safety organizations globally struggling to regulate and control its market. Over the course of this study, the aim was to determine the origin of EVOOs suggesting a high-throughput, state-of-the-art method that could be easily adopted. A rapid, NMR-based untargeted metabolite profiling method was applied and complemented by multivariate analysis (MVA) and statistical total correlation spectroscopy (STOCSY). STOCSY is a valuable statistical tool contributing to the biomarker identification process and was employed for the first time in EVOO analysis. Market samples from three Mediterranean countries of Spain, Italy, and Greece, blended samples from these countries, as well as monocultivar samples from Greece were analyzed. The NMR spectra were collected, with the help of chemometrics acting as "fingerprints" leading to the discovery of certain chemical classes and single biomarkers that were related to the classification of the samples into groups based on their origin.

Indexed as

Olive OilItalyMagnetic Resonance SpectroscopyMultivariate AnalysisSpainOlive Oilbiomarkersbotanical originextra virgin olive oil—EVOOfoodomicsgeographical originmetabolite profilingNMR spectroscopyOlea europaea L.STOCSY

Identifiers

PMID36838725
PMCPMC9966212

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.