Evidence map›Paper›PMID 36838702›Full record

ArticleMolecules (Basel, Switzerland)2023

Manipulating the Subcellular Localization and Anticancer Effects of Benzophenothiaziniums by Minor Alterations of N-Alkylation.

Yanping Wu, Yuncong Chen, Shankun Yao, Shumeng Li, Hao Yuan, Fen Qi, Weijiang He, Zijian Guo

Open access · goldAbstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.1field-weighted citation impact, top 64% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

ALDH Inhibition-Primed Photocatalysis Disrupts Cancer Stemness Plasticity.Angewandte Chemie (International ed. in English) · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yanping WuState Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Yuncong ChenState Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.ORCID 0000-0002-8406-4866

Shankun YaoState Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Shumeng LiState Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Hao YuanState Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Fen QiState Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Weijiang HeState Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Zijian GuoState Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.ORCID 0000-0003-4986-9308

Nanjing University · CN

Funding

Excellent Research Program of Nanjing University ZYJH004Jiangsu Province Science and Technology Department BK20202004National Natural Science Foundation of China 22122701, 21731004, 91953201, 92153303, 21977044

6 · The paper itself

Abstract

Cationic, water-soluble benzophenothiaziniums have been recognized as effective type I photosensitizers (PSs) against hypoxic tumor cells. However, the study of the structure-property relationship of this type of PS is still worth further exploration to achieve optimized photodynamic effects and minimize the potential side effects. Herein, we synthesized a series of benzophenothiazine derivatives with minor N-alkyl alteration to study the effects on the structure-property relationships. The cellular uptake, subcellular organelle localization, reactive oxygen species (ROS) generation, and photocytotoxicity performances were systematically investigated. NH

Indexed as

PhotochemotherapyPhotosensitizing AgentsAlkylationAnimalsCell Line, TumorHumansMicePhenothiazinesThiazines5-ethylamino-9-diethylaminobenzo(a)phenothiaziniumbenzophenothiazinePhenothiazinesPhotosensitizing AgentsThiazinesbenzophenothiaziniumslysosomal membrane permeabilizationmitochondria membrane potentialnicotinamide adenine dinucleotide phosphatephotodynamic therapyphototoxicity indexreactive oxygen speciestype I photosensitizers

Identifiers

PMID36838702

DOI10.3390/molecules28041714

PMCPMC9965410

OpenAlexW4320205844

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.