Evidence map›Paper›PMID 36838674›Full record

ReviewMolecules (Basel, Switzerland)2023

An Undefined Interaction between Polyamines and Heat Shock Proteins Leads to Cellular Protection in

Xolani H Makhoba, Rino Ragno, Annette Kaiser, Enzo Agostinelli

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Therapeutic Insights intoPharmaceuticals (Basel, Switzerland) · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Xolani H MakhobaDepartment of Biochemistry, Microbiology, and Biotechnology, School of Molecular and Life Science, University of Limpopo, Turfloop Campus, Sovenga 0727, South Africa.ORCID 0000-0002-7238-4619
Rino RagnoRome Center for Molecular Design, Department of Drug Chemistry and Technology, Sapienza University, P. le A. Moro 5, 00185 Rome, Italy.ORCID 0000-0001-5399-975X
Annette KaiserMedical Research Centre, University of Duisburg-Essen, Hufeland Strasse 55, 45147 Essen, Germany.ORCID 0000-0001-7873-3958
Enzo AgostinelliDepartment of Sensory Organs, Sapienza University of Rome, Policlinico Umberto I, Viale del Policlinico 155, 00161 Rome, Italy.ORCID 0000-0002-2508-8868
Policlinico Umberto I · ITSapienza University of Rome · ITUniversity of Duisburg-Essen · DEUniversity of Limpopo · ZA

Funding

Federal Ministry of Education and Research ERANETPLUS 2019-466-3
6 · The paper itself

Abstract

Environmental stimuli can distress the internal reaction of cells and their normal function. To react promptly to sudden environmental changes, a cascade of heat shock proteins (Hsps) functions to protect and act as housekeepers inside the cells. In parallel to the heat shock response, the metabolic polyamine (PA) status changes. Here, we discuss possible ways of putative interactions between Hsps and polyamines in a wide lineage of eukaryotic model organisms with a particular focus on parasitic protozoa such as

Indexed as

Heat-Shock ProteinsMalaria, FalciparumPlasmodiumPolyaminesAnimalsHSP70 Heat-Shock ProteinsHumansPlasmodium falciparumSpermidineHeat-Shock ProteinsHSP70 Heat-Shock ProteinsPolyaminesSpermidinecancerheat shock proteinsplants and drug discoveryPlasmodium falciparumpolyamines

Identifiers

PMID36838674
PMCPMC9958663
OpenAlexW4319984955

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.