Evidence map›Paper›PMID 36838664›Full record

ArticleMolecules (Basel, Switzerland)2023

A Stability-Indicating Assay for Tetrahydrocurcumin-Diglutaric Acid and Its Applications to Evaluate Bioaccessibility in an In Vitro Digestive Model.

Nattapong Jongjitphisut, Worathat Thitikornpong, Wisut Wichitnithad, Thanundorn Thanusuwannasak, Opa Vajragupta, Pornchai Rojsitthisak

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nattapong JongjitphisutPharmaceutical Sciences and Technology Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Worathat ThitikornpongCenter of Excellence in Natural Products for Ageing and Chronic Diseases, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0000-0002-3537-3646
Wisut WichitnithadDepartment of Analytical and Clinical Development, Pharma Nueva Co., Ltd., Bangkok 10900, Thailand.ORCID 0000-0001-5991-1843
Thanundorn ThanusuwannasakCU Drug and Health Products Innovation Promotion Center, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Opa VajraguptaCenter of Excellence in Natural Products for Ageing and Chronic Diseases, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0000-0003-3313-0621
Pornchai RojsitthisakCenter of Excellence in Natural Products for Ageing and Chronic Diseases, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0000-0003-1391-6993
Chulalongkorn University · TH

Funding

Chulalongkorn University GCE 6503433003-1Chulalongkorn University GCUGR1125642014MChulalongkorn University HEA663300006
6 · The paper itself

Abstract

A simple and reliable ultra-high-performance liquid chromatographic (UHPLC) method was developed and validated for determination of tetrahydrocurcumin diglutaric acid (TDG) and applied for evaluation of its bioaccessibility. The analytical method was validated to demonstrate as a stability-indicating assay (SIA) according to the ICH Q2(R1) guidelines under various force degradation conditions including thermal degradation, moisture, acid and base hydrolysis, oxidation, and photolysis. The developed chromatographic condition could completely separate all degradants from the analyte of interest. The method linearity was verified in the range of 0.4-12 μg/mL with the coefficient of determination (r

Indexed as

CurcuminChromatography, High Pressure LiquidDrug StabilityLimit of DetectionReproducibility of ResultsCurcumintetrahydrocurcuminbioaccessibilitystability indicating assaytetrahydrocurcumin diglutaric acid (TDG)tetrahydrocurcumin (THC)UHPLCvalidation

Identifiers

PMID36838664
PMCPMC9966976
OpenAlexW4319985031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.