Evidence map›Paper›PMID 36838660›Full record

ArticleMolecules (Basel, Switzerland)2023

Molecular Modeling and In Vitro Evaluation of Piplartine Analogs against Oral Squamous Cell Carcinoma.

Rayanne H N Silva, Thaíssa Q Machado, Anna Carolina C da Fonseca, Eduardo Tejera, Yunierkis Perez-Castillo, Bruno K Robbs, Damião P de Sousa

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Rayanne H N SilvaLaboratory of Pharmaceutical Chemistry, Department of Pharmaceutical Sciences, Federal University of Paraíba, Cidade Universitária, João Pessoa 58051-900, Brazil.
Thaíssa Q MachadoPostgraduate Program in Applied Science for Health Products, Faculty of Pharmacy, Fluminense Federal University, Niteroi 24241-000, Brazil.
Anna Carolina C da FonsecaPostgraduate Program in Dentistry, Health Institute of Nova Friburgo, Fluminense Federal University, Nova Friburgo 28625-650, Brazil.ORCID 0000-0002-8366-3146
Eduardo TejeraBio-Cheminformatics Research Group, Universidad de Las Américas, Quito 170516, Ecuador.
Yunierkis Perez-CastilloFacultad de Ingeniería y Ciencias Aplicadas, Área de Ciencias Aplicadas, Universidad de Las Américas, Quito 170516, Ecuador.ORCID 0000-0002-3710-0035
Bruno K RobbsDepartamento de Ciência Básica, Instituto de Saúde de Nova Friburgo, Universidade Federal Fluminense, Nova Friburgo 28625-650, Brazil.ORCID 0000-0002-3972-5530
Damião P de SousaLaboratory of Pharmaceutical Chemistry, Department of Pharmaceutical Sciences, Federal University of Paraíba, Cidade Universitária, João Pessoa 58051-900, Brazil.ORCID 0000-0002-7180-4896
Universidade Federal Fluminense · BRUniversidad de Las Américas · ECUniversidade Federal da Paraíba · BR

Funding

Apoio aos Programas e Cursos de Pós-graduação Stricto Sensu do Estado do Rio de Janeiro E-26/210.068/2021Coordination for the Improvement of Higher Education Personnel-Brazil (CAPES) Finance Code 001Coordination for the Improvement of Higher Education Personnel (CAPES). E-26/202,787/2019National Council for Scientific and Technological Development (CNPq) 306729/2019-9Produtividade em Pesquisa PROPESQ/PRPG/UFPB PIG14859-2021
6 · The paper itself

Abstract

Cancer is a principal cause of death in the world, and providing a better quality of life and reducing mortality through effective pharmacological treatment remains a challenge. Among malignant tumor types, squamous cell carcinoma-esophageal cancer (EC) is usually located in the mouth, with approximately 90% located mainly on the tongue and floor of the mouth. Piplartine is an alkamide found in certain species of the genus

Indexed as

Mouth NeoplasmsSquamous Cell Carcinoma of Head and NeckCell Line, TumorHumansPiperidonesQuality of LifePiperidonespiperlonguminealkaloidanticancerantitumorcytotoxicitymedicinal plantsnatural productsPiperpiplartine

Identifiers

PMID36838660
PMCPMC9964404
OpenAlexW4319983931

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.