ReviewMolecules (Basel, Switzerland)2023
Ugi Four-Component Reactions Using Alternative Reactants.
Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Multicomponent Reactions for the Synthesis of Oxazepines.Topics in current chemistry (Cham) · 2026Review
- Extended insight into the catalytic activity of boron-doped graphitic carbon nitride for the synthesis of bis-pyrazolyl methanes and pyranopyrazoles.Scientific reports · 2025Article
- One-Pot Synthesis of Antibacterial and Antioxidant Self-Healing Bioadhesives Using Ugi Four-Component Reactions.Journal of biomedical materials research. Part B, Applied biomaterials · 2025Article
- Exploring Phthalimide as the Acid Component in the Passerini Reaction.Organic letters · 2024Article
- One-pot Ugi-azide and Heck reactions for the synthesis of heterocyclic systems containing tetrazole and 1,2,3,4-tetrahydroisoquinoline.Beilstein journal of organic chemistry · 2024Article
- Multicomponent reactions driving the discovery and optimization of agents targeting central nervous system pathologies.Beilstein journal of organic chemistry · 2024Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Ugi four-component reaction (Ugi-4CR) undoubtedly is the most prominent multicomponent reaction (MCRs) that has sparked organic chemists' interest in the field. It has been widely used in the synthesis of diverse heterocycle molecules such as potential drugs, natural product analogs, pseudo peptides, macrocycles, and functional materials. The Ugi-4CRs involve the use of an amine, an aldehyde or ketone, an isocyanide, and a carboxylic acid to produce an α-acetamido carboxamide derivative, which has significantly advanced the field of isocyanide-based MCRs. The so-called intermediate nitrilium ion could be trapped by a nucleophile such as azide,
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Registered trials
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