Evidence map›Paper›PMID 36838317›Full record

ReviewMicroorganisms2023

Probiotics in Functional Dyspepsia.

Georgios Tziatzios, Paraskevas Gkolfakis, Gabriela Leite, Ruchi Mathur, Georgia Damoraki, Evangelos J Giamarellos-Bourboulis, Konstantinos Triantafyllou

Open access · goldAbstract readReview
In one paragraph

Review in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Investigating the Health Potential ofPharmaceuticals (Basel, Switzerland) · 2025
    Review
  4. Review
  5. Article
  6. Probiotics and the intestinal tight junction barrier function.Frontiers in cell and developmental biology · 2025
    Review
  7. Microorganisms · 2024
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Georgios TziatziosDepartment of Gastroenterology, "Konstantopoulio-Patision" General Hospital, 3-5, Theodorou Konstantopoulou Street, Nea Ionia, 142 33 Athens, Greece.ORCID 0000-0002-2945-6007
Paraskevas GkolfakisDepartment of Gastroenterology, "Konstantopoulio-Patision" General Hospital, 3-5, Theodorou Konstantopoulou Street, Nea Ionia, 142 33 Athens, Greece.ORCID 0000-0002-9677-4013
Gabriela LeiteMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA 90048, USA.
Ruchi MathurMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA 90048, USA.
Georgia Damoraki4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, 157 72 Athens, Greece.
Evangelos J Giamarellos-Bourboulis4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, 157 72 Athens, Greece.ORCID 0000-0003-4713-3911
Konstantinos TriantafyllouHepatogastroenterology Unit, Second Department of Internal Medicine-Propaedeutic, Medical School, Research Institute and Diabetes Center, "Attikon" University General Hospital, National and Kapodistrian University of Athens, 124 62 Athens, Greece.ORCID 0000-0002-5183-9426
National and Kapodistrian University of Athens · GRAgia Olga Hospital · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functional dyspepsia (FD) is a common disorder in everyday clinical practice identified nowadays as a multi-factorial, difficult to treat condition with a significant burden on patients' quality of life (QoL) and healthcare systems worldwide. Despite its high prevalence in the general population, the precise etiology of the disorder remains elusive, with its pathophysiological spectrum evolving over time, including variable potential mechanisms, i.e., impaired gastric accommodation, gastric motor disorders, hypersensitivity to gastric distention, disorders of the brain-gut axis, as well as less evident ones, i.e., altered duodenal microbiota composition and genetic susceptibility. In light of these implications, a definitive, universal treatment that could be beneficial for all FD patients is not available yet. Recently, probiotics have been suggested to be an effective therapeutic option that could alleviate gastrointestinal symptoms in patients with Irritable Bowel Syndrome (IBS), potentially due to anti-inflammatory properties or by modulating the complex bidirectional interactions between gastrointestinal microbiota and host crosstalk; however, their impact on the multiple aspects of FD remains ambiguous. In this review, we aim to summarize all currently available evidence for the efficacy of probiotics as a novel therapeutic approach for FD.

Indexed as

dyspepsiafunctionalprobioticstreatment

Identifiers

PMID36838317
PMCPMC9964889
OpenAlexW4318706103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.