Evidence map›Paper›PMID 36838311›Full record

ArticleMicroorganisms2023

Exploration of the Nuclear Proteomes in the Ciliate

Michael W Lu, Leslie Y Beh, V Talya Yerlici, Wenwen Fang, Katarzyna Kulej, Benjamin A Garcia, Laura F Landweber

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Michael W LuDepartment of Biological Sciences, Columbia University, New York, NY 10025, USA.ORCID 0000-0002-4926-8839
Leslie Y BehDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.
V Talya YerliciDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.ORCID 0000-0001-5408-0518
Wenwen FangRNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA 01655, USA.
Katarzyna KulejDivision of Protective Immunity and Division of Cancer Pathobiology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Benjamin A GarciaDepartment of Biochemistry and Molecular Biophysics, Washington University in St. Louis, St. Louis, MO 63130, USA.
Laura F LandweberDepartment of Biological Sciences, Columbia University, New York, NY 10025, USA.ORCID 0000-0002-7030-8540
Columbia University · USChildren's Hospital of Philadelphia · USUniversity of Massachusetts Chan Medical School · USWashington University in St. Louis · US

Funding

Shared Resources Core 2: Quantitative Proteomics CoreP01CA196539 · NCI · ROCKEFELLER UNIVERSITY · PI MUIR, TOM · 2015 to 2024
$17.6M
Understanding Complex Genome Editing and RNA Biology in OxytrichaR35GM122555 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LAURA F LANDWEBER · 2017 to 2026
$7.9M
CELLULAR AND MOLECULAR FOUNDATIONS OF BIOMEDICAL SCIENCET32GM008798 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI PRYWES, RON M · 2001 to 2018
$6.3M
Viral modulation of epitranscriptomic mechanismsR01AI118891 · NIAID · WASHINGTON UNIVERSITY · PI GARCIA, BENJAMIN A, WEITZMAN, MATTHEW D. · 2015 to 2025
$5.4M
NCI NIH HHS P01 CA196539NIAID NIH HHS R01 AI118891NIGMS NIH HHS R35 GM122555NIGMS NIH HHS R35GM122555NIGMS NIH HHS T32 GM008798
6 · The paper itself

Abstract

Nuclear dimorphism is a fundamental feature of ciliated protozoa, which have separate somatic and germline genomes in two distinct organelles within a single cell. The transcriptionally active somatic genome, contained within the physically larger macronucleus, is both structurally and functionally different from the silent germline genome housed in the smaller micronucleus. This difference in genome architecture is particularly exaggerated in

Indexed as

ciliatehistonemacronucleusmicronucleusnuclear proteomeOxytrichaproteomics

Identifiers

PMID36838311
PMCPMC9958989
OpenAlexW4318483713

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.