Evidence map›Paper›PMID 36838306›Full record

ReviewMicroorganisms2023

Epigenetic Targets and Pathways Linked to SARS-CoV-2 Infection and Pathology.

Ali A Rabaan, Mohammed Aljeldah, Basim R Al Shammari, Roua A Alsubki, Jawaher Alotaibi, Yousef N Alhashem, Neda A Alali, Tarek Sulaiman, Zainab Alsalem, Huda A Bajunaid and 10 more

Open access · goldAbstract readReview
In one paragraph

Review in Microorganisms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Landscape of NFrontiers in microbiology · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 15 institutions in 4 countries.

Ali A RabaanMolecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia.ORCID 0000-0002-6774-9847
Mohammed AljeldahDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Hafr Al Batin, Hafr Al Batin 39831, Saudi Arabia.ORCID 0000-0001-5335-2809
Basim R Al ShammariDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Hafr Al Batin, Hafr Al Batin 39831, Saudi Arabia.ORCID 0000-0002-3522-0607
Roua A AlsubkiDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11362, Saudi Arabia.ORCID 0000-0002-1741-0933
Jawaher AlotaibiInfectious Diseases Unit, Department of Medicine, King Faisal Specialist Hospital and Research Center, Riyadh 11564, Saudi Arabia.ORCID 0000-0002-1653-4117
Yousef N AlhashemClinical Laboratory Science Department, Mohammed Al-Mana College for Medical Sciences, Dammam 34222, Saudi Arabia.ORCID 0000-0003-4435-3003
Neda A AlaliPediatric Department, Security Force Hospital, Riyadh 13526, Saudi Arabia.
Tarek SulaimanInfectious Diseases Section, Medical Specialties Department, King Fahad Medical City, Riyadh 12231, Saudi Arabia.
Zainab AlsalemDepartment of Epidemic Diseases Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Huda A BajunaidMakkah Specialized Laboratory, Fakeeh Care Group, Hadda 25321, Saudi Arabia.
Mohammed GaroutDepartment of Community Medicine and Health Care for Pilgrims, Faculty of Medicine, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Heba A AlsaffarDepartment of Azizia Primary Health Care, Ministry of Health, Dammam 32211, Saudi Arabia.
Souad A AlmuthreeDepartment of Infectious Disease, King Abdullah Medical City, Makkah 43442, Saudi Arabia.
Doha HudhaiahMicrobiology Laboratory, King Fahad University Hospital, Al Khobar 34445, Saudi Arabia.
Azhar M AlzaherImprovement of Operation Department, Qatif Health Network, Qatif 31911, Saudi Arabia.
Fatimah A AlshaikhInfection Prevention and Control Department, Qatif Central Hospital, Qatif 32654, Saudi Arabia.
Amer AlshengetiDepartment of Pediatrics, College of Medicine, Taibah University, Al-Madinah 41491, Saudi Arabia.ORCID 0000-0001-6861-6934
Mustafa A NajimDepartment of Medical Laboratories Technology, College of Applied Medical Sciences, Taibah University, Madinah 41411, Saudi Arabia.
Ramadan Abdelmoez FarahatFaculty of Medicine, Kafrelsheikh University, Kafrelsheikh 33511, Egypt.ORCID 0000-0002-6263-0812
Ranjan K MohapatraDepartment of Chemistry, Government College of Engineering, Keonjhar 758002, India.ORCID 0000-0001-7623-3343
Qatif Central Hospital · SATaibah University · SAUniversity of Hafr Al-Batin · SAAlfaisal University · SAGovernment College of Engineering, Keonjhar · INImam Abdulrahman Bin Faisal University · SAKafrelsheikh University · EGKing Abdullah Medical City · SAKing Fahd Hospital of the University · SAKing Fahd Medical City · SAKing Faisal Specialist Hospital & Research Centre · SAKing Saud University · SAMinistry of Health · SASecurity Forces Hospital · SAUmm al-Qura University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The scale at which the SARS-CoV-2/COVID-19 pandemic has spread remains enormous. Provided the genetic makeup of the virus and humans is readily available, the quest for knowing the mechanism and epidemiology continues to prevail across the entire scientific community. Several aspects, including immunology, molecular biology, and host-pathogen interaction, are continuously being dug into for preparing the human race for future pandemics. The exact reasons for vast differences in symptoms, pathophysiological implications of COVID-infections, and mortality differences remain elusive. Hence, researchers are also looking beyond traditional genomics, proteomics, and transcriptomics approach, especially entrusting the environmental regulation of the genetic landscape of COVID-human interactions. In line with these questions lies a critical process called epigenetics. The epigenetic perturbations in both host and parasites are a matter of great interest to unravel the disparities in COVID-19 mortalities and pathology. This review provides a deeper insight into current research on the epigenetic landscape of SARS-CoV-2 infection in humans and potential targets for augmenting the ongoing investigation. It also explores the potential targets, pathways, and networks associated with the epigenetic regulation of processes involved in SARS-CoV-2 pathology.

Indexed as

COVID-19COVID-pathologydrug targetsepigeneticsSARS-CoV-2

Identifiers

PMID36838306
PMCPMC9967649
OpenAlexW4318479011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.