Evidence map›Paper›PMID 36838088›Full record

ArticleMicromachines2023

Facile Fabrication of Silk Fibroin/Off-Stoichiometry Thiol-Ene (OSTE) Microneedle Array Patches.

Yuqian Yang, Zhiqing Xiao, Lexin Sun, Zitao Feng, Zejingqiu Chen, Weijin Guo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Micromachines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Yuqian YangDepartment of Biomedical Engineering, Shantou University, Shantou 515063, China.ORCID 0000-0002-7714-5756
Zhiqing XiaoDepartment of Biomedical Engineering, Shantou University, Shantou 515063, China.ORCID 0000-0002-1412-2995
Lexin SunDepartment of Biomedical Engineering, Shantou University, Shantou 515063, China.ORCID 0000-0002-1480-3184
Zitao FengDepartment of Biomedical Engineering, Shantou University, Shantou 515063, China.ORCID 0000-0002-8618-0852
Zejingqiu ChenDepartment of Biology, Shantou University, Shantou 515063, China.
Weijin GuoDepartment of Biomedical Engineering, Shantou University, Shantou 515063, China.ORCID 0000-0003-2444-6771
Shantou University · CNUniversity of Michigan · US

Funding

Department of Education of Guangdong Province 2022KQNCX019Guangdong Basic and Applied Basic Research Foundation 2022A1515110855Shantou University NTF20034
6 · The paper itself

Abstract

Microneedles have been used in various applications in biomedical engineering, including drug delivery, biosensing, and vaccine delivery. In this study, we develop a novel protocol to fabricate silk fibroin/off-stoichiometry thiol-ene (OSTE) hybrid microneedle array patches. Silk fibroin, as a natural biomaterial, has been proven to be suitable as a drug carrier. Firstly, drug (we use insulin in this experiment) dissolved in silk fibroin solution is deposited on a microneedle mold and dried thoroughly. After that, silk fibroin needle tips are formed on the OSTE base by replica molding. We investigated the influence of the silk fibroin concentration on the length of silk needle tips and found that the silk concentration had a small influence on the tip length. We also tested the mechanical strength of the microneedles by inserting them into gelatin gel for dummy drug delivery tests. Such composite structures have the potential to increase the delivery efficiency by delivering the whole silk tip into the dermis.

Indexed as

drug deliveryinsulinmicroneedleoff-stoichiometry thiol-eneOSTEreplica moldingsilk fibroin

Identifiers

PMID36838088
PMCPMC9964817
OpenAlexW4319316913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.