ReviewMetabolites2023
Pregnancy Toxemia in Ewes: A Review of Molecular Metabolic Mechanisms and Management Strategies.
Review in Metabolites, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Characterization of Fecal Microbiota and Serum Metabolome Variations Across Different Gestational Stages in Hu Sheep.Animals : an open access journal from MDPI · 2026Article
- Gut microbiota and meat quality in ruminants: a review of mechanisms and microbiota-targeted interventions.Food science of animal resources · 2026Review
- Late-stage pregnancy toxemia in does: biochemical, hormonal, and histopathological changes.Tropical animal health and production · 2026Article
- Periparturient alpha-lipoic acid supplementation improves ewe antioxidant status, colostrum quality, and lamb growth.Tropical animal health and production · 2026Article
- Protective effect of dietary L-carnitine supplementation on follicular development in the ovary of ewes with subclinical pregnancy toxemia.Archives animal breeding · 2026Article
- Metabolic, adipokine (irisin, spexin, visfatin), and ER stress (GRP78) responses in multiparous Brown Swiss cows: a multivariate approach across physiological stages and body condition scores.Archives animal breeding · 2026Article
- Genomic Variants, Transcriptomic Profile, Ultrasonographic Findings, and Antioxidant and Immunological Biomarkers Linked to Pregnancy Toxemia Susceptibility in Goats.Veterinary sciences · 2025Article
- Comparative Evaluation of Different Blood Collection Sites for the Assessment of Beta-Hydroxybutyric Acid Concentrations Using a Handheld Meter in Sheep.Veterinary medicine and science · 2025Article
- Subcutaneous Buprenorphine Is an Acceptable Preoperative Analgesic in Pregnant Ewes Undergoing Hysterotomy (Ovis aries).Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Undernutrition disrupts jejunal and ileal microbiota and epithelial tissue homeostasis in a pregnant sheep model.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Failure in the mother-young communication in domestic mammals: endocrine and behavioral aspects.Frontiers in veterinary science · 2025Review
- Glucose Metabolism-Modifying Natural Materials for Potential Feed Additive Development.Pharmaceutics · 2024Review
- Helminth Parasite Prevalence in the Endangered Ethiopian Wolf (Journal of parasitology research · 2024Article
- Relationship between rumen microbiota and pregnancy toxemia in ewes.Frontiers in veterinary science · 2024Article
- Identification of risk factors for ewe mortality during the pregnancy and lambing period in extensively managed flocks.BMC veterinary research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Pregnancy toxemia is a nutritional metabolic disease during late gestation in small ruminants. The condition is characterized by disorders in carbohydrate and fat metabolism. Obese and multiparous ewes are particularly susceptible to pregnancy toxemia, which may lead to maternal death, abortion, or premature birth. Highly productive multiparous meat ewes are major breeding animals, which has led to an increased incidence of the disease. However, the pathogenesis of pregnancy toxemia remains unclear and adequate disease prevention and treatment strategies are absent. Investigating the pathogenesis of pregnancy toxemia, especially the metabolic pathways of hepatic lipids, is key to an improved understanding of the condition. This review provides a snapshot of the genes that are associated with lipid metabolism in the ovine liver, including genes involved in fatty acid oxidation, acetyl coenzyme metabolism, and triglyceride synthesis; describes the interrelationships between these genes; and summarizes the diagnosis, prevention, and treatment of pregnancy toxemia.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.