Evidence map›Paper›PMID 36837683›Full record

ArticleMembranes2023

Asbestos Fibers Enhance the TMEM16A Channel Activity in Xenopus Oocytes.

Annalisa Bernareggi, Martina Zangari, Andrew Constanti, Paola Zacchi, Violetta Borelli, Alessandro Mangogna, Paola Lorenzon, Giuliano Zabucchi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Membranes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Effect of Synthetic Vitreous Fiber Exposure on TMEM16A Channels in aInternational journal of molecular sciences · 2024
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Annalisa BernareggiDepartment of Life Sciences, University of Trieste, Via Fleming 22, 34127 Trieste, Italy.ORCID 0000-0002-7007-8466
Martina ZangariDepartment of Life Sciences, University of Trieste, Via Fleming 22, 34127 Trieste, Italy.
Andrew ConstantiDepartment of Pharmacology, UCL School of Pharmacy, 29/39 Brunswick Square, London WC1N 1AX, UK.
Paola ZacchiDepartment of Life Sciences, University of Trieste, Via Valerio 28/1, 34127 Trieste, Italy.
Violetta BorelliDepartment of Life Sciences, University of Trieste, Via Valerio 28/1, 34127 Trieste, Italy.
Alessandro MangognaInstitute for Maternal and Child Health-IRCCS Burlo Garofolo, Via Dell'Istria 65/1, 34137 Trieste, Italy.ORCID 0000-0001-7910-1274
Paola LorenzonDepartment of Life Sciences, University of Trieste, Via Fleming 22, 34127 Trieste, Italy.ORCID 0000-0002-9526-6471
Giuliano ZabucchiDepartment of Life Sciences, University of Trieste, Via Valerio 28/1, 34127 Trieste, Italy.
University of Trieste · ITIRCCS Materno Infantile Burlo Garofolo · ITUniversity College London · GB

Funding

Italian League for the Fight Against Cancer (Lega Italiana Lotta contro i Tumori, LILT, Gorizia section, Italy, Bando Ricerca Sanitaria 2017-programma 5 per mille anno 2015), Regione Friuli Venezia Giulia (Contributi alle Aziende Sanitarie per la realizza none
6 · The paper itself

Abstract

backgroundThe interaction of asbestos fibers with target cell membranes is still poorly investigated. Here, we detected and characterized an enhancement of chloride conductance in

methodsA two-microelectrode voltage clamp technique was used to test the effect of Croc fiber suspensions on outward chloride currents evoked by step membrane depolarization. Calcium imaging experiments were also performed to investigate the variation of 'resting' oocyte [Ca

resultsThe increase in chloride current after asbestos treatment, was sensitive to [Ca

conclusionthe TMEM16A channels endogenously expressed by

Indexed as

asbestos fiberscrocidoliteTMEM16A channelsvoltage clampXenopus oocytes

Identifiers

PMID36837683
PMCPMC9960392
OpenAlexW4319019057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.