Evidence map›Paper›PMID 36837682›Full record

ArticleMembranes2023

Preparation and Characterization of Chitosan/LDH Composite Membranes for Drug Delivery Application.

Elena-Ruxandra Radu, Andreea Madalina Pandele, Cristina Tuncel, Florin Miculescu, Stefan Ioan Voicu

Open access · goldAbstract read
In one paragraph

Article in Membranes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Design of chitosan-coated CeORSC medicinal chemistry · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Elena-Ruxandra RaduDepartment of Analytical Chemistry and Environmental Engineering, Faculty of Chemical Engineering and Biotechnologies University Politehnica of Bucharest, 011061 Bucharest, Romania.
Andreea Madalina PandeleAdvanced Polymers Materials Group, University Politehnica of Bucharest, 011061 Bucharest, Romania.
Cristina TuncelDepartment of Analytical Chemistry and Environmental Engineering, Faculty of Chemical Engineering and Biotechnologies University Politehnica of Bucharest, 011061 Bucharest, Romania.
Florin MiculescuDepartment of Metallic Materials Science, Physical Metallurgy, University Politehnica of Bucharest, 313 Splaiul Independentei, J Building, 060042 Bucharest, Romania.ORCID 0000-0001-6757-5616
Stefan Ioan VoicuDepartment of Analytical Chemistry and Environmental Engineering, Faculty of Chemical Engineering and Biotechnologies University Politehnica of Bucharest, 011061 Bucharest, Romania.ORCID 0000-0001-7191-7471
Universitatea Națională de Știință și Tehnologie Politehnica București · RO

Funding

Unitatea Executiva Pentru Finantarea Invatamantului Superior a Cercetarii Dezvoltarii si Inovarii PN-III-P4-ID-PCE-2020-1154
6 · The paper itself

Abstract

In this study, composite membranes based on chitosan (CS), layered double hydroxide (LDH), and diclofenac were prepared via dispersing of LDH and diclofenac (DCF) in the chitosan matrix for gradual delivery of diclofenac sodium. The effect of using LDH in composites was compared to chitosan loaded with diclofenac membrane. LDH was added in order to develop a system with a long release of diclofenac sodium, which is used in inflammatory conditions as an anti-inflammatory drug. The prepared composite membranes were characterized by Fourier Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscope Analysis (SEM), X-ray Photoelectron Spectroscopy (XPS), Thermogravimetric Analysis (TGA) and UV-Vis Spectroscopy. The results of the FTIR and XPS analyses confirmed the obtaining of the composite membrane and the efficient incorporation of diclofenac. It was observed that the addition of LDH can increase the thermal stability of the composite membrane and favors the gradual release of diclofenac, highlighted by UV-Vis spectra that showed a gradual release in the first 48 h. In conclusion, the composite membrane based on CS-LDH can be used in potential drug delivery application.

Indexed as

chitosancomposite membranesdiclofenacdrug deliveryLDH

Identifiers

PMID36837682
PMCPMC9965179
OpenAlexW4318776589

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.