Evidence map›Paper›PMID 36837566›Full record

ArticleMedicina (Kaunas, Lithuania)2023

Antibodies against Serum Anti-Melanoma Differentiation-Associated Gene 5 in Rheumatoid Arthritis Patients with Chronic Lung Diseases.

Shomi Oka, Takashi Higuchi, Hiroshi Furukawa, Kota Shimada, Akira Okamoto, Atsushi Hashimoto, Akiko Komiya, Koichiro Saisho, Norie Yoshikawa, Masao Katayama and 4 more

Open access · goldAbstract read
In one paragraph

Article in Medicina (Kaunas, Lithuania), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Shomi OkaDepartment of Rheumatology, National Hospital Organization Tokyo National Hospital, 3-1-1 Takeoka, Kiyose 204-8585, Japan.
Takashi HiguchiDepartment of Rheumatology, National Hospital Organization Tokyo National Hospital, 3-1-1 Takeoka, Kiyose 204-8585, Japan.
Hiroshi FurukawaDepartment of Rheumatology, National Hospital Organization Tokyo National Hospital, 3-1-1 Takeoka, Kiyose 204-8585, Japan.ORCID 0000-0003-1353-8056
Kota ShimadaDepartment of Rheumatology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Japan.ORCID 0000-0002-2860-4266
Akira OkamotoDepartment of Rheumatology, National Hospital Organization Himeji Medical Center, 68 Hon-machi, Himeji 670-8520, Japan.
Atsushi HashimotoDepartment of Rheumatology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Japan.
Akiko KomiyaClinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Japan.
Koichiro SaishoDepartment of Orthopedics/Rheumatology, National Hospital Organization Miyakonojo Medical Center, 5033-1 Iwayoshi-cho, Miyakonojo 885-0014, Japan.
Norie YoshikawaDepartment of Orthopedics/Rheumatology, National Hospital Organization Miyakonojo Medical Center, 5033-1 Iwayoshi-cho, Miyakonojo 885-0014, Japan.
Masao KatayamaDepartment of Internal Medicine, National Hospital Organization Nagoya Medical Center, 4-1-1 Sannomaru, Naka-ku, Nagoya 460-0001, Japan.
Toshihiro MatsuiClinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Japan.
Naoshi FukuiClinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Japan.
Kiyoshi MigitaClinical Research Center, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura 856-8562, Japan.
Shigeto TohmaDepartment of Rheumatology, National Hospital Organization Tokyo National Hospital, 3-1-1 Takeoka, Kiyose 204-8585, Japan.
National Sagamihara Hospital · JPNational Hospital Organization · JPFukushima Medical University · JPHimeji Medical Center · JPImamura Hospital · JPTokyo National Hospital · JP

Funding

Abbott Japan Co., Ltd.Astellas Pharma Inc.Bristol-Myers Squibb Co.Chugai Pharmaceutical Co., Ltd.Daiwa Securities Health FoundationEisai Co., Ltd.Japan Agency for Medical Research and DevelopmentJapan Research Foundation for Clinical PharmacologyMerck Sharp and Dohme Inc.Mitsubishi Tanabe Pharma CorporationMitsui Sumitomo Insurance Welfare FoundationNational Hospital OrganizationPfizer Japan Inc.Takeda Pharmaceutical Company LimitedTakeda Science FoundationTeijin Pharma Limitedthe Japan Society for the Promotion of Science 22591090, 26293123, 15K09543, 18K08402the Ministry of Health, Labour, and Welfare of JapanThe Nakatomi Foundation
6 · The paper itself

Abstract

Chronic lung diseases (CLD), including interstitial lung disease (ILD) and airway diseases (ADs), are common complications of rheumatoid arthritis (RA). Rheumatoid factor (RF) and anti-citrullinated peptide antibodies are reported to be associated with CLD in RA patients. The presence of anti-melanoma differentiation-associated gene 5 (MDA5) antibodies (Abs) is associated with clinically amyopathic dermatomyositis developing into rapidly progressive ILD. However, few studies on anti-MDA5 Abs in RA have been published. Here, we analyzed the association of anti-MDA5 Abs with CLD complications in RA. Anti-MDA5 Abs were quantified in sera from RA patients with or without CLD. Anti-MDA5 Ab levels were higher in RA patients with ADs than without (mean ± SDM, 4.4 ± 2.4 vs. 4.0 ± 4.2,

Indexed as

Arthritis, RheumatoidDermatomyositisLung Diseases, InterstitialAutoantibodiesHumansInterferon-Induced Helicase, IFIH1Retrospective StudiesAutoantibodiesInterferon-Induced Helicase, IFIH1airway diseasesanti-melanoma differentiation-associated gene 5 antibodieschronic lung diseaserheumatoid arthritis

Identifiers

PMID36837566
PMCPMC9962840
OpenAlexW4320918278

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.