Evidence map›Paper›PMID 36837564›Full record

ReviewMedicina (Kaunas, Lithuania)2023

Vaccines and Autoimmunity-From Side Effects to ASIA Syndrome.

Isa Seida, Ravend Seida, Abdulrahman Elsalti, Naim Mahroum

Open access · goldAbstract readReview
In one paragraph

Review in Medicina (Kaunas, Lithuania), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Autoimmune manifestations recorded after SARS-CoV-2 vaccination.Clinical and experimental vaccine research · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
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  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Isa SeidaInternational School of Medicine, Istanbul Medipol University, 34810 Istanbul, Turkey.
Ravend SeidaInternational School of Medicine, Istanbul Medipol University, 34810 Istanbul, Turkey.
Abdulrahman ElsaltiInternational School of Medicine, Istanbul Medipol University, 34810 Istanbul, Turkey.ORCID 0000-0002-4130-3978
Naim MahroumInternational School of Medicine, Istanbul Medipol University, 34810 Istanbul, Turkey.ORCID 0000-0002-7919-1326
Istanbul Medipol University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since vaccines are in fact manufactured chemical compounds such as drugs, the appearance of side effects following their use is not surprising. Similarly, as the main goal of vaccines is to stimulate the immune system bringing out the production of protective antibodies, autoimmune-related side effects as a consequence of increased immune activity do not seem irrational. Fortunately, the rate of such side effects is low; however, the importance of reporting adverse events following vaccinations, understanding the mechanisms behind their appearance, making early diagnosis, and appropriate treatment cannot be overemphasized. In fact, autoimmune-related side effects of vaccines, particularly those based on adjuvants, were reported long before the introduction of the autoimmune/inflammatory syndrome induced by adjuvants (ASIA). Nevertheless, ASIA gathered and united the side effects of vaccines under one title, a step which helped organize the research and call for better immune stimulators than adjuvants. New technologies and methods of making vaccines were clearly noticed during the pandemic of COVID-19 after the introduction of mRNA-based vaccines. In our current paper, we introduce the notion of side effects to vaccines, particularly those of autoimmune nature, the mechanisms of ASIA, and the main vaccines linked with the syndrome including the recent COVID-19 vaccines. The transition from side effects to ASIA is the main idea behind our work.

Indexed as

Autoimmune DiseasesCOVID-19COVID-19 VaccinesDrug-Related Side Effects and Adverse ReactionsAdjuvants, ImmunologicAutoimmunityHumansmRNA VaccinesSyndromeVaccinesAdjuvants, ImmunologicCOVID-19 VaccinesmRNA VaccinesVaccinesadjuvantASIACOVID-19hepatitis B vaccineinfluenza vaccine

Identifiers

PMID36837564
PMCPMC9966463
OpenAlexW4320920937

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.