Evidence map›Paper›PMID 36837418›Full record

ArticleMedicina (Kaunas, Lithuania)2023

Epstein-Barr Virus-Positive Cutaneous and Systemic Plasmacytosis with TAFRO Syndrome-like Symptoms Successfully Treated with Rituximab.

Seiji Kakiuchi, Hiroaki Akiyama, Isamu Harima, Ikumi Takagi, Junpei Rikitake, Yoko Kozuki, Mayumi Inaba, Hiroshi Fujiwara, Nozomu Kurose, Sohsuke Yamada and 1 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicina (Kaunas, Lithuania), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. TAFRO Syndrome and COVID-19.Biomedicines · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Seiji KakiuchiDepartment of Hematology, Yodogawa Christian Hospital, 1-7-50, Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan.ORCID 0000-0002-2065-1957
Hiroaki AkiyamaDepartment of Hematology, Yodogawa Christian Hospital, 1-7-50, Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan.
Isamu HarimaDepartment of Hematology, Yodogawa Christian Hospital, 1-7-50, Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan.
Ikumi TakagiDepartment of Hematology, Yodogawa Christian Hospital, 1-7-50, Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan.
Junpei RikitakeDepartment of Hematology, Yodogawa Christian Hospital, 1-7-50, Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan.
Yoko KozukiDepartment of Hematology, Yodogawa Christian Hospital, 1-7-50, Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan.
Mayumi InabaDepartment of Pathology, Yodogawa Christian Hospital, 1-7-50, Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan.
Hiroshi FujiwaraDepartment of Respiratory Medicine, Yodogawa Christian Hospital, 1-7-50, Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan.
Nozomu KuroseDepartment of Pathology and Laboratory Medicine, Kanazawa Medical University, 1-1, Daigaku, Uchinada, Kahoku 920-0293, Ishikawa, Japan.
Sohsuke YamadaDepartment of Pathology and Laboratory Medicine, Kanazawa Medical University, 1-1, Daigaku, Uchinada, Kahoku 920-0293, Ishikawa, Japan.ORCID 0000-0003-2662-0024
Yasufumi MasakiDepartment of Hematology and Immunology, Kanazawa Medical University, 1-1, Daigaku, Uchinada, Kahoku 920-0293, Ishikawa, Japan.ORCID 0000-0002-5658-3765
Yodogawa Christian Hospital · JPKanazawa Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Histopathologic findings in the lymph nodes of patients with thrombocytopenia, anasarca, fever, reticulin fibrosis, renal dysfunction, and organomegaly (TAFRO) syndrome are similar to those of idiopathic multicentric Castleman's disease (iMCD), but TAFRO syndrome is different from iMCD in how it can progress rapidly and be fatal. These patients present scarce lymphadenopathy and low immunoglobulin levels. We present a case of cutaneous and systemic plasmacytosis (C/SP) that caused TAFRO syndrome-like symptoms which were successfully treated with rituximab. A 67-year-old woman presented with fever and a pruritic skin rash. Numerous plasma cells were observed in the peripheral blood and imaging revealed organomegaly, anasarca, and generalized lymphadenopathy. Subsequently, she rapidly developed thrombocytopenia as well as renal and heart failure. She tested positive for the Epstein-Barr virus (EBV), elevated immunoglobulins, and C/SP, which are also atypical for TAFRO syndrome, thereby complicating the diagnosis. However, after using the Japanese TAFRO Syndrome Research Group diagnostic criteria, we promptly administered rituximab to treat the C/SP with TAFRO-like symptoms and saved her life. Finally, histopathological observations of the lymph node biopsy helped confirm EBV-positive hypervascular-type iMCD. Therefore, diagnosing TAFRO-like syndromes based on the Japanese diagnostic criteria and following the associated treatment even without a confirmed diagnosis is crucial to improving the patient outcomes.

Indexed as

Epstein-Barr Virus InfectionsLymphadenopathyThrombocytopeniaAgedCastleman DiseaseEdemaFemaleHerpesvirus 4, HumanHumansRituximabRituximabcutaneous and systemic plasmacytosisEpstein–Barr virusidiopathic multicentric Castleman’s diseaserituximabTAFRO syndrome

Identifiers

PMID36837418
PMCPMC9962959
OpenAlexW4317740359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.