Evidence map›Paper›PMID 36836874›Full record

ReviewLife (Basel, Switzerland)2023

Regulation of Liver Glucose and Lipid Metabolism by Transcriptional Factors and Coactivators.

Balamurugan Ramatchandirin, Alexia Pearah, Ling He

Open access · goldAbstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. CD38 Inhibition Enhances FXR Signaling in Male Rats With Diabetic Steatohepatitis Through SIRT1-Dependent Suppression of NLRP3.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
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  6. Frontiers in immunology · 2026
    Article
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Balamurugan RamatchandirinDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0003-0390-1878
Alexia PearahDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Ling HeDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Johns Hopkins University · US

Funding

Coactivator P300 promotes hepatic steatosis in obesityR01DK120309 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI HE, LING, YU, LIQING · 2019 to 2023
$2.7M
Activation of the cAMP-PKA pathway antagonizes metformin actionR01DK107641 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI HE, LING · 2016 to 2020
$1.8M
6 · The paper itself

Abstract

The prevalence of nonalcoholic fatty liver disease (NAFLD) worldwide is on the rise and NAFLD is becoming the most common cause of chronic liver disease. In the USA, NAFLD affects over 30% of the population, with similar occurrence rates reported from Europe and Asia. This is due to the global increase in obesity and type 2 diabetes mellitus (T2DM) because patients with obesity and T2DM commonly have NAFLD, and patients with NAFLD are often obese and have T2DM with insulin resistance and dyslipidemia as well as hypertriglyceridemia. Excessive accumulation of triglycerides is a hallmark of NAFLD and NAFLD is now recognized as the liver disease component of metabolic syndrome. Liver glucose and lipid metabolisms are intertwined and carbon flux can be used to generate glucose or lipids; therefore, in this review we discuss the important transcription factors and coactivators that regulate glucose and lipid metabolism.

Indexed as

fatty liverobesitytype 2 diabetes

Identifiers

PMID36836874
PMCPMC9962321
OpenAlexW4320728860

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.