Evidence map›Paper›PMID 36836757›Full record

ReviewLife (Basel, Switzerland)2023

Protein and Lipid Content of Milk Extracellular Vesicles: A Comparative Overview.

Sandra Buratta, Lorena Urbanelli, Alessia Tognoloni, Raffaella Latella, Giada Cerrotti, Carla Emiliani, Elisabetta Chiaradia

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Life (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07402083 (Administration of Extracellular Vesicles Isolated From Donor Human Milk as a Dietary Supplement for the Prevention of Necrotizing Enterocolitis in Preterm Infants), which is not on this map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07402083 recruitingnot on this mapstarted 2026, after this paper: background citation

Administration of Extracellular Vesicles Isolated From Donor Human Milk as a Dietary Supplement for the Prevention of Necrotizing Enterocolitis in Preterm Infants

TypeobservationalSponsorInstituto de Investigacion Sanitaria La FeRan2026 to 2029Enrolled20ConditionsVery Preterm Infants (<32 Weeks of Gestation)ArmsDonor human milk extracellular vesicles (DHM-EVs)
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sandra BurattaDepartment of Chemistry, Biology and Biotechnology, University of Perugia, 06123 Perugia, Italy.
Lorena UrbanelliDepartment of Chemistry, Biology and Biotechnology, University of Perugia, 06123 Perugia, Italy.ORCID 0000-0003-0621-8476
Alessia TognoloniDepartment of Veterinary Medicine, University of Perugia, 06126 Perugia, Italy.
Raffaella LatellaDepartment of Chemistry, Biology and Biotechnology, University of Perugia, 06123 Perugia, Italy.
Giada CerrottiDepartment of Chemistry, Biology and Biotechnology, University of Perugia, 06123 Perugia, Italy.
Carla EmilianiDepartment of Chemistry, Biology and Biotechnology, University of Perugia, 06123 Perugia, Italy.
Elisabetta ChiaradiaDepartment of Veterinary Medicine, University of Perugia, 06126 Perugia, Italy.ORCID 0000-0002-0958-9187
University of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The characterization of the protein and lipid cargo of milk extracellular vesicles from different mammal species is crucial for understanding their biogenesis and biological functions, as well as for a comprehensive description of the nutritional aspects of animal milk for human diet. In fact, milk EVs have been reported to possess relevant biological effects, but the molecules/biochemical pathways underlying these effects have been poorly investigated. The biochemical characterization is an important initial step for the potential therapeutic and diagnostic use of natural or modified milk EVs. The number of studies analysing the protein and lipid composition of milk EVs is limited compared to that investigating the nucleic acid cargo. Here, we revised the literature regarding the protein and lipid content of milk EVs. Until now, most investigations have shown that the biochemical cargo of EVs is different with respect to that of other milk fractions. In addition, even if these studies derived mostly from bovine and human milk EVs, comparison between milk EVs from different animal species and milk EVs biochemical composition changes due to different factors including lactation stages and health status is also beginning to be reported.

Indexed as

exosomeextracellular vesiclelipidomicsmilkproteomics

Identifiers

PMID36836757
PMCPMC9962516
OpenAlexW4318831782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.