Evidence map›Paper›PMID 36836209›Full record

ArticleJournal of clinical medicine2023

Risankizumab Therapy for Moderate-to-Severe Psoriasis-A Multi-Center, Long-Term, Real-Life Study from Poland.

Michał Adamczyk, Joanna Bartosińska, Dorota Raczkiewicz, Kinga Adamska, Zygmunt Adamski, Maria Czubek, Beata Kręcisz, Elżbieta Kłujszo, Aleksandra Lesiak, Joanna Narbutt and 12 more

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Michał AdamczykDepartment of Dermatology, Venereology and Pediatric Dermatology Medical University of Lublin, 20-081 Lublin, Poland.ORCID 0000-0001-8713-7840
Joanna BartosińskaDepartment of Dermatology, Venereology and Pediatric Dermatology Medical University of Lublin, 20-081 Lublin, Poland.ORCID 0000-0003-4106-3051
Dorota RaczkiewiczDepartment of Medical Statistics, School of Public Health, Center of Postgraduate Medical Education, 01-826 Warsaw, Poland.
Kinga AdamskaDepartment of Dermatology, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
Zygmunt AdamskiDepartment of Dermatology, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
Maria CzubekDepartament of Dermatology Copernicus Sp z o.o., Podmiot Leczniczy Gdańsk, 80-803 Gdańsk, Poland.
Beata KręciszDepartment of Dermatology, Jan Kochanowski University of Kielce, 25-406 Kielce, Poland.
Elżbieta KłujszoDepartment of Dermatology, Jan Kochanowski University of Kielce, 25-406 Kielce, Poland.
Aleksandra LesiakDepartment of Pediatric Dermatology and Oncology, Medical University of Łódź, 92-215 Łódź, Poland.
Joanna NarbuttDepartment of Pediatric Dermatology and Oncology, Medical University of Łódź, 92-215 Łódź, Poland.
Marcin NowetaDepartment of Pediatric Dermatology and Oncology, Medical University of Łódź, 92-215 Łódź, Poland.
Agnieszka Owczarczyk-SaczonekDepartment of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, The University of Warmia and Mazury, 10-229 Olsztyn, Poland.ORCID 0000-0002-8372-0438
Witold OwczarekDepartment of Dermatology, Military Institute of Medicine, 04-141 Warsaw, Poland.
Adam ReichDepartment of Dermatology, Institute of Medical Sciences, Medical College of Rzeszow University, 35-055 Rzeszów, Poland.ORCID 0000-0002-5573-1754
Dominik SamotijDepartment of Dermatology, Institute of Medical Sciences, Medical College of Rzeszow University, 35-055 Rzeszów, Poland.
Aleksandra SiekierkoDepartment of Pediatric Dermatology and Oncology, Medical University of Łódź, 92-215 Łódź, Poland.
Justyna SzczęchDepartment of Dermatology, Institute of Medical Sciences, Medical College of Rzeszow University, 35-055 Rzeszów, Poland.
Irena WaleckaCentre of Postgraduate Medical Education, Dermatology Department, Central Clinical Hospital of the Ministry of the Interior and Administration, 02-507 Warsaw, Poland.ORCID 0000-0002-3502-3339
Piotr CiechanowiczCentre of Postgraduate Medical Education, Dermatology Department, Central Clinical Hospital of the Ministry of the Interior and Administration, 02-507 Warsaw, Poland.
Anna WoźniackaDepartment of Dermatology and Venereology, Medical University of Łódź, 90-419 Łódź, Poland.
Agata LiszewskaDepartment of Dermatology and Venereology, Medical University of Łódź, 90-419 Łódź, Poland.
Dorota KrasowskaDepartment of Dermatology, Venereology and Pediatric Dermatology Medical University of Lublin, 20-081 Lublin, Poland.ORCID 0000-0002-3176-9870

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present multi-center, long-term, real-life study made an attempt to assess the efficacy of risankizumab in the treatment of moderate-to-severe plaque psoriasis. The study comprised 185 patients from 10 Polish dermatologic departments undergoing risankizumab treatment. The disease severity was measured using the Psoriasis Area and Severity Index (PASI) before the start of the risankizumab treatment and next at the defined timepoints, i.e., 4, 16, 28, 40, 52 and 96 weeks of treatment. The percentage of patients achieving PASI90 and PASI100 responses as well as the PASI percentage decrease at the defined timepoints were calculated, and correlations with clinical characteristics and therapeutic effect were analyzed. The number of patients evaluated at the defined timepoints was: 136, 145, 100, 93, 62, and 22 at 4, 16, 28, 40, 52 and 96 weeks of treatment, respectively. At 4, 16, 28, 40, 52 and 96 weeks, the PASI90 response was achieved in 13.2%, 81.4%, 87.0%, 86.0%, 88.7% and 81.8% of patients, whereas the PASI100 response was achieved in 2.9%, 53.1%, 67.0%, 68.8%, 71.0% and 68.2% of patients, respectively. Our study revealed a significant negative correlation between a decrease in the PASI and the presence of psoriatic arthritis as well as the patient's age and duration of psoriasis at several timepoints throughout the observation period.

Indexed as

biologic treatmentpsoriasisreal-life experiencerisankizumabsystemic treatment

Identifiers

PMID36836209
PMCPMC9959800

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.