Evidence map›Paper›PMID 36835989›Full record

ReviewJournal of clinical medicine2023

Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics.

Samradhi Singh, Namrata Pal, Swasti Shubham, Devojit Kumar Sarma, Vinod Verma, Francesco Marotta, Manoj Kumar

2 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 248 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
248citing papers in PubMed, 19 pooled it
106.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07328048 naenrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Combine Effects of Senobi Exercise & Aerobic Exercises on Body Mass Index, Fatigue and Quality of Life in Polycystic Ovarian Syndrome.

TypeinterventionalSponsorRiphah International UniversityRan2026 to 2026Enrolled32ConditionsPolycystic Ovarian Syndrome FemalesArmsSenobi exercises with aerobics exercises, aerobic exercises
NCT07399535 phase1completednot on this mapstarted 2025, after this paper: background citation

Clinical Investigation of Herbal Formulation and Its Efficacy in Polycystic Ovarian Syndrome

TypeinterventionalSponsorJinnah Postgraduate Medical CentreRan2025 to 2026Enrolled116ConditionsPolycystic Ovarian Syndrome (PCOS), Herbal Medicine, Infertility, Metabolic DisorderArmsHerbal Formulation, Metformin XR, Metformin 750 mg and herbal formulation 500 mg
3 · Its place in the literature

Who cites it

248 citing papers in PubMed, 19 syntheses or guidelines pooled it, 388 citations in OpenAlex.

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188 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Samradhi SinghICMR-National Institute for Research in Environmental Health, Bhopal Bypass Road, Bhopal 462030, India.ORCID 0000-0003-1841-6429
Namrata PalICMR-National Institute for Research in Environmental Health, Bhopal Bypass Road, Bhopal 462030, India.
Swasti ShubhamICMR-National Institute for Research in Environmental Health, Bhopal Bypass Road, Bhopal 462030, India.
Devojit Kumar SarmaICMR-National Institute for Research in Environmental Health, Bhopal Bypass Road, Bhopal 462030, India.ORCID 0000-0002-2749-4114
Vinod VermaStem Cell Research Centre, Department of Hematology, Sanjay Gandhi Post-Graduate Institute of MedicalSciences, Lucknow 226014, India.
Francesco MarottaReGenera R&D International for Aging Intervention, 20144 Milano, Lombardia, Italy.
Manoj KumarICMR-National Institute for Research in Environmental Health, Bhopal Bypass Road, Bhopal 462030, India.ORCID 0000-0002-2040-8631
ICMR National Institute for Research in Environmental HealthSanjay Gandhi Post Graduate Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder, typically characterized by anovulation, infertility, obesity, insulin resistance, and polycystic ovaries. Lifestyle or diet, environmental pollutants, genetics, gut dysbiosis, neuroendocrine alterations, and obesity are among the risk factors that predispose females to PCOS. These factors might contribute to upsurging metabolic syndrome by causing hyperinsulinemia, oxidative stress, hyperandrogenism, impaired folliculogenesis, and irregular menstrual cycles. Dysbiosis of gut microbiota may play a pathogenic role in the development of PCOS. The restoration of gut microbiota by probiotics, prebiotics, or a fecal microbiota transplant (FMT) might serve as an innovative, efficient, and noninvasive way to prevent and mitigate PCOS. This review deliberates on the variety of risk factors potentially involved in the etiology, prevalence, and modulation of PCOS, in addition to plausible therapeutic interventions, including miRNA therapy and the eubiosis of gut microbiota, that may help treat and manage PCOS.

Indexed as

FMTgut dysbiosisgut microbiomehyperandrogenismhyperinsulinemiametabolic disordersmiRNA therapyPCOSprobiotics

Identifiers

PMID36835989
PMCPMC9964744
OpenAlexW4320494004

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.