Evidence map›Paper›PMID 36835961›Full record

ArticleJournal of clinical medicine2023

A Potential Therapy Using Antisense Oligonucleotides to Treat Autosomal Recessive Polycystic Kidney Disease.

Huixia Li, Chunli Wang, Ruochen Che, Bixia Zheng, Wei Zhou, Songming Huang, Zhanjun Jia, Aihua Zhang, Fei Zhao, Guixia Ding

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Expansion of Splice-Switching Therapy with Antisense Oligonucleotides.International journal of molecular sciences · 2025
    Review
  3. RNA-Based Therapies in Kidney Diseases.Journal of inflammation research · 2025
    Review
  4. Gene therapy in polycystic kidney disease: A promising future.Journal of translational internal medicine · 2024
    Article
  5. Article
  6. Review
  7. Article
  8. Novel Therapies inKidney international reports · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Huixia LiDepartment of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing 210008, China.
Chunli WangNanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing 210008, China.
Ruochen CheDepartment of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing 210008, China.
Bixia ZhengNanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing 210008, China.ORCID 0000-0003-3457-6545
Wei ZhouNanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing 210008, China.
Songming HuangNanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing 210008, China.
Zhanjun JiaNanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing 210008, China.ORCID 0000-0002-3107-0429
Aihua ZhangNanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing 210008, China.
Fei ZhaoDepartment of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing 210008, China.
Guixia DingDepartment of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing 210008, China.
Second Affiliated Hospital of Nanjing Medical University · CN

Funding

National Natural Science Foundation of China 82070688 and 81974084the Health Science and Technology Development Special Foundation of Nanjing grant. no. ZKX21047 and grant. no. ZKX19040
6 · The paper itself

Abstract

(1) Background: Autosomal recessive polycystic kidney disease (ARPKD) is a rare ciliopathy characterized by progressively enlarged kidneys with fusiform dilatation of the collecting ducts. Loss-of-function mutations in the

Indexed as

ASOsautosomal recessive polycystic kidney diseaseexon skippingPKHD1splicing variant

Identifiers

PMID36835961
PMCPMC9966971
OpenAlexW4320496510

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.