Evidence map›Paper›PMID 36835818›Full record

ArticleJournal of clinical medicine2023

Heart Failure Association-International Cardio-Oncology Society Risk Score Validation in HER2-Positive Breast Cancer.

Michael Cronin, Aileen Crowley, Matthew G Davey, Peter Ryan, Mahmoud Abdelshafy, Ahmed Elkoumy, Hesham Elzomor, Shahram Arsang-Jang, Sandra Ganly, Patrick Nash and 7 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Artificial intelligence-enhanced electrocardiography for prediction of cancer therapy-related cardiac dysfunction.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
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  10. Cardio-oncology: chances and challenges.Basic research in cardiology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Michael CroninDiscipline of Cardiology, Galway University Hospital, Health Service Executive, H91 TK33 Galway, Ireland.
Aileen CrowleyDiscipline of Cardiology, Galway University Hospital, Health Service Executive, H91 TK33 Galway, Ireland.
Matthew G DaveyDiscipline of Surgery, Lambe Institute for Translational Research, University of Galway, H91 TK33 Galway, Ireland.ORCID 0000-0002-9892-9920
Peter RyanCORRIB Core Lab., University of Galway, H91 TK33 Galway, Ireland.
Mahmoud AbdelshafyDiscipline of Cardiology, Galway University Hospital, Health Service Executive, H91 TK33 Galway, Ireland.ORCID 0000-0003-1040-0019
Ahmed ElkoumyDiscipline of Cardiology, Galway University Hospital, Health Service Executive, H91 TK33 Galway, Ireland.ORCID 0000-0002-6325-1056
Hesham ElzomorDiscipline of Cardiology, Galway University Hospital, Health Service Executive, H91 TK33 Galway, Ireland.
Shahram Arsang-JangCORRIB Core Lab., University of Galway, H91 TK33 Galway, Ireland.ORCID 0000-0001-7476-0414
Sandra GanlyPrecision Cardio-Oncology Research Enterprise (P-CORE), H91 TK33 Galway, Ireland.
Patrick NashDiscipline of Cardiology, Galway University Hospital, Health Service Executive, H91 TK33 Galway, Ireland.
James CrowleyDiscipline of Cardiology, Galway University Hospital, Health Service Executive, H91 TK33 Galway, Ireland.
Faisal SharifDiscipline of Cardiology, Galway University Hospital, Health Service Executive, H91 TK33 Galway, Ireland.
Andrew SimpkinCORRIB Core Lab., University of Galway, H91 TK33 Galway, Ireland.
Aoife LoweryDiscipline of Surgery, Lambe Institute for Translational Research, University of Galway, H91 TK33 Galway, Ireland.
William WijnsDiscipline of Cardiology, Galway University Hospital, Health Service Executive, H91 TK33 Galway, Ireland.
Michael KerinDiscipline of Surgery, Lambe Institute for Translational Research, University of Galway, H91 TK33 Galway, Ireland.
Osama SolimanDiscipline of Cardiology, Galway University Hospital, Health Service Executive, H91 TK33 Galway, Ireland.ORCID 0000-0003-0758-3539
Ollscoil na Gaillimhe – University of Galway · IEUniversity Hospital Galway · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis paper looks to validate the risk score from the Heart Failure Association of the European Society of Cardiology and the International Cardio-Oncology Society (HFA-ICOS) for predicting potential cardiotoxicity from anticancer therapy for patients positive for human epidermal growth factor receptor 2.

methodsA total of 507 patients with at least five years since index diagnosis of breast cancer were retrospectively divided according to the HFA-ICOS risk proforma. According to level of risk, these groups were assessed for rates of cardiotoxicity via mixed-effect Bayesian logistic regression model.

resultsA follow-up of five years observed cardiotoxicity of 3.3% (

conclusionsThe HFA-ICOS risk score has moderate power in predicting cancer therapy-related cardiotoxicity in HER2-positive breast cancer patients.

Indexed as

anthracyclinebreast cancerheart failureHER2 therapyrisk prediction

Identifiers

PMID36835818
PMCPMC9963986
OpenAlexW4319298000

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.