Evidence map›Paper›PMID 36835737›Full record

ArticleInsects2023

Functionally Validating Evolutionary Conserved Risk Genes for Parkinson's Disease in

Amalie Elton Baisgaard, Kristina Magaard Koldby, Torsten Nygård Kristensen, Mette Nyegaard, Palle Duun Rohde

Open access · goldAbstract read
In one paragraph

Article in Insects, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Insects · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Amalie Elton BaisgaardDepartment of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.
Kristina Magaard KoldbyDepartment of Health Science and Technology, Aalborg University, 9220 Aalborg, Denmark.ORCID 0000-0003-1951-5736
Torsten Nygård KristensenDepartment of Chemistry and Bioscience, Aalborg University, 9220 Aalborg, Denmark.ORCID 0000-0001-6204-8753
Mette NyegaardDepartment of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.ORCID 0000-0003-4973-8543
Palle Duun RohdeDepartment of Health Science and Technology, Aalborg University, 9220 Aalborg, Denmark.ORCID 0000-0003-4347-8656
Aalborg University · DKAarhus University · DK

Funding

Danish Parkinson Society and Bjarne Saxhofs Found R20-A494-B337Novo Nordisk Foundation NNF19OC0058619Novo Nordisk Foundation NNF21OC0071050
6 · The paper itself

Abstract

Parkinson's disease (PD) is a heterogeneous and complex neurodegenerative disorder and large-scale genetic studies have identified >130 genes associated with PD. Although genomic studies have been decisive for our understanding of the genetic contributions underlying PD, these associations remain as statistical associations. Lack of functional validation limits the biological interpretation; however, it is labour extensive, expensive, and time consuming. Therefore, the ideal biological system for functionally validating genetic findings must be simple. The study aim was to assess systematically evolutionary conserved PD-associated genes using

Indexed as

climbing abilitymodel organismneurodegenerative diseaseRING assay

Identifiers

PMID36835737
PMCPMC9958964
OpenAlexW4319985492

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.