Evidence map›Paper›PMID 36835663›Full record

ArticleInternational journal of molecular sciences2023

Microbiome Dysbiosis Shows Strong Association of Gut-Derived Altered Metabolomic Profile in Gulf War Chronic Multisymptom Illness Symptom Persistence Following Western Diet Feeding and Development of Obesity.

Dipro Bose, Vitalli Stebliankin, Trevor Cickovski, Punnag Saha, Ayushi Trivedi, Subhajit Roy, Madhura More, Ashok Tuteja, Kalai Mathee, Giri Narasimhan and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Dipro BoseEnvironmental Health and Disease Laboratory, Department of Environmental and Occupational Health, Program in Public Health, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, CA 92697, USA.
Vitalli StebliankinKnight Foundation School of Computing and Information Sciences, College of Engineering and Computing, Florida International University, Miami, FL 33199, USA.ORCID 0000-0001-9377-0263
Trevor CickovskiKnight Foundation School of Computing and Information Sciences, College of Engineering and Computing, Florida International University, Miami, FL 33199, USA.ORCID 0000-0003-2724-6951
Punnag SahaEnvironmental Health and Disease Laboratory, Department of Environmental and Occupational Health, Program in Public Health, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, CA 92697, USA.ORCID 0000-0001-6173-9798
Ayushi TrivediEnvironmental Health and Disease Laboratory, Department of Environmental and Occupational Health, Program in Public Health, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, CA 92697, USA.
Subhajit RoyEnvironmental Health and Disease Laboratory, Department of Environmental and Occupational Health, Program in Public Health, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, CA 92697, USA.
Madhura MoreEnvironmental Health and Disease Laboratory, Department of Environmental and Occupational Health, Program in Public Health, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, CA 92697, USA.
Ashok TutejaDivision of Internal Medicine, University of Utah School of Medicine, Salt Lake City VAMC, Salt Lake City, UT 84132, USA.ORCID 0000-0002-4509-1976
Kalai MatheeDepartment of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA.ORCID 0000-0003-4569-5419
Giri NarasimhanKnight Foundation School of Computing and Information Sciences, College of Engineering and Computing, Florida International University, Miami, FL 33199, USA.ORCID 0000-0003-0535-4871
Saurabh ChatterjeeEnvironmental Health and Disease Laboratory, Department of Environmental and Occupational Health, Program in Public Health, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, CA 92697, USA.ORCID 0000-0003-1649-7149
University of California, Irvine · USFlorida International University · USUniversity of Utah · US

Funding

CSRD VA I01 CX001923
6 · The paper itself

Abstract

The pathophysiology of Gulf War Illness (GWI) remains elusive even after three decades. The persistence of multiple complex symptoms along with metabolic disorders such as obesity worsens the health of present Gulf War (GW) Veterans often by the interactions of the host gut microbiome and inflammatory mediators. In this study, we hypothesized that the administration of a Western diet might alter the host metabolomic profile, which is likely associated with the altered bacterial species. Using a five-month symptom persistence GWI model in mice and whole-genome sequencing, we characterized the species-level dysbiosis and global metabolomics, along with heterogenous co-occurrence network analysis, to study the bacteriome-metabolomic association. Microbial analysis at the species level showed a significant alteration of beneficial bacterial species. The beta diversity of the global metabolomic profile showed distinct clustering due to the Western diet, along with the alteration of metabolites associated with lipid, amino acid, nucleotide, vitamin, and xenobiotic metabolism pathways. Network analysis showed novel associations of gut bacterial species with metabolites and biochemical pathways that could be used as biomarkers or therapeutic targets to ameliorate symptom persistence in GW Veterans.

Indexed as

DysbiosisGastrointestinal MicrobiomeAnimalsBacteriaDiet, WesternGulf WarMiceObesitychronic multisymptom illnessgutmetabolomemicrobiomewhole-genome sequencing

Identifiers

PMID36835663
PMCPMC9962797
OpenAlexW4321459559

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.