SynthesisInternational journal of molecular sciences2023
Peptide Designs for Use in Caries Management: A Systematic Review.
Synthesis in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Bactericidal and Antibiofilm Activities of HT-2-1-3, a Vespidae Venom-Derived Antimicrobial Peptide, AgainstAntibiotics (Basel, Switzerland) · 2026Article
- Next-Gen Restorative Materials to Revolutionise Smiles.Bioengineering (Basel, Switzerland) · 2026Review
- Antimicrobial Peptides as Novel Ecological Approaches to Caries Prevention.Drug design, development and therapy · 2026Review
- Optimization strategies for antimicrobial peptides in dental caries prevention and management: from emerging mechanisms of action to clinical translation.Frontiers in microbiology · 2026Review
- Rational Design of a Bioconjugated Antitumor Peptide with Tumor-Selective Targeting and Microenvironment-Responsive Activation.Pharmaceutical research · 2026Article
- Comparison of salivary statherin and beta-defensin-2 levels, oral health behaviors, and demographic factors in children with and without early childhood caries.BMC oral health · 2025Article
- FTIR,Combinatorial chemistry & high throughput screening · 2024Article
- Development of a Novel Peptide with Antimicrobial and Mineralising Properties for Caries Management.Pharmaceutics · 2023Article
- Antibacterial Properties of the Antimicrobial Peptide Gallic Acid-Polyphemusin I (GAPI).Antibiotics (Basel, Switzerland) · 2023Article
- Bioactive Materials for Caries Management: A Literature Review.Dentistry journal · 2023Review
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
The objective of this study was to review the design methods that have been used to create peptides for use in caries management. Two independent researchers systematically reviewed many in vitro studies in which peptides were designed for use in caries management. They assessed the risk of bias in the included studies. This review identified 3592 publications, of which 62 were selected. Forty-seven studies reported 57 antimicrobial peptides. Among them, 31 studies (66%, 31/47) used the template-based design method; 9 studies (19%, 9/47) used the conjugation method; and 7 studies (15%, 7/47) used other methods, such as the synthetic combinatorial technology method, the de novo design method and cyclisation. Ten studies reported mineralising peptides. Seven of these (70%, 7/10) used the template-based design method, two (20%, 2/10) used the de novo design method, and one study (10%, 1/10) used the conjugation method. In addition, five studies developed their own peptides with antimicrobial and mineralising properties. These studies used the conjugation method. Our assessment for the risk of bias in the 62 reviewed studies showed that 44 publications (71%, 44/62) had a medium risk and that 3 publications had a low risk (5%, 3/62). The two most common methods for developing peptides for use in caries management that were used in these studies were the template-based design method and the conjugation method.
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