Evidence map›Paper›PMID 36835649›Full record

ReviewInternational journal of molecular sciences2023

Advances in Liquid Biopsy Technology and Implications for Pancreatic Cancer.

Alexander G Raufi, Michael S May, Matthew J Hadfield, Attila A Seyhan, Wafik S El-Deiry

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

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  18. Trials and Tribulations of MicroRNA Therapeutics.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Alexander G RaufiDivision of Hematology/Oncology, Department of Medicine, Lifespan Health System, Providence, RI 02903, USA.
Michael S MayDivision of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-6187-4655
Matthew J HadfieldDivision of Hematology/Oncology, Department of Medicine, Lifespan Health System, Providence, RI 02903, USA.
Attila A SeyhanLegorreta Cancer Center, Brown University, Providence, RI 02903, USA.ORCID 0000-0003-1276-8466
Wafik S El-DeiryDivision of Hematology/Oncology, Department of Medicine, Lifespan Health System, Providence, RI 02903, USA.
Brown University · USColumbia University Irving Medical Center · US

Funding

Molecular Oncology Training ProgramT32CA203703 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Katherine D Crew, DAWN HERSHMAN · 2016 to 2026
$4.1M
CAPRI: Columbia Cancer Training Program for Resident-InvestigatorsR38CA231577 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CREW, KATHERINE D, SCHWARTZ, GARY K · 2018 to 2021
$1.4M
NCI NIH HHS R38 CA231577NCI NIH HHS T32 CA203703
6 · The paper itself

Abstract

Pancreatic cancer is a highly aggressive malignancy with a climbing incidence. The majority of cases are detected late, with incurable locally advanced or metastatic disease. Even in individuals who undergo resection, recurrence is unfortunately very common. There is no universally accepted screening modality for the general population and diagnosis, evaluation of treatment response, and detection of recurrence relies primarily on the use of imaging. Identification of minimally invasive techniques to help diagnose, prognosticate, predict response or resistance to therapy, and detect recurrence are desperately needed. Liquid biopsies represent an emerging group of technologies which allow for non-invasive serial sampling of tumor material. Although not yet approved for routine use in pancreatic cancer, the increasing sensitivity and specificity of contemporary liquid biopsy platforms will likely change clinical practice in the near future. In this review, we discuss the recent technological advances in liquid biopsy, focusing on circulating tumor DNA, exosomes, microRNAs, and circulating tumor cells.

Indexed as

Circulating Tumor DNAMicroRNAsNeoplastic Cells, CirculatingPancreatic NeoplasmsBiomarkers, TumorHumansLiquid BiopsyBiomarkers, TumorCirculating Tumor DNAMicroRNAsCTCsctDNAsexosomesliquid biopsymiRNAspancreatic ductal adenocarcinoma

Identifiers

PMID36835649
PMCPMC9958987
OpenAlexW4321458181

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.