Evidence map›Paper›PMID 36835568›Full record

ArticleInternational journal of molecular sciences2023

The Crosstalk between Intestinal Epithelial Cells and Mast Cells Is Modulated by the Probiotic Supplementation in Co-Culture Models.

Raffaella di Vito, Alessia Di Mezza, Carmela Conte, Giovanna Traina

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. The interplay between probiotics and mast cells in gut inflammation: a mini-review.Frontiers in cellular and infection microbiology · 2026
    Review
  4. Article
  5. Article
  6. A Probiotic Mixture ofInternational journal of molecular sciences · 2025
    Article
  7. Review
  8. Article
  9. Mast Cells in Human Health and Diseases 2.0.International journal of molecular sciences · 2024
    Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Raffaella di VitoDepartment of Pharmaceutical Sciences, University of Perugia, Via Romana, 06126 Perugia, Italy.ORCID 0000-0003-1661-3517
Alessia Di MezzaDepartment of Pharmaceutical Sciences, University of Perugia, Via Romana, 06126 Perugia, Italy.
Carmela ConteDepartment of Pharmaceutical Sciences, University of Perugia, Via Romana, 06126 Perugia, Italy.ORCID 0000-0003-2456-6300
Giovanna TrainaDepartment of Pharmaceutical Sciences, University of Perugia, Via Romana, 06126 Perugia, Italy.ORCID 0000-0001-9996-3584
University of Perugia · IT

Funding

University of Perugia 6RICBASE20University of Perugia 6RICBASE21
6 · The paper itself

Abstract

The intestinal epithelium constitutes a selectively permeable barrier between the internal and external environment that allows the absorption of nutrients, electrolytes, and water, as well as an effective defense against intraluminal bacteria, toxins, and potentially antigenic material. Experimental evidence suggest that intestinal inflammation is critically dependent on an imbalance of homeostasis between the gut microbiota and the mucosal immune system. In this context, mast cells play a crucial role. The intake of specific probiotic strains can prevent the development of gut inflammatory markers and activation of the immune system. Here, the effect of a probiotic formulation containing

Indexed as

Mast CellsProbioticsCaco-2 CellsCoculture TechniquesEpithelial CellsHumansIntestinal MucosaLipopolysaccharidesLipopolysaccharidesCaco-2HMC-1.2HT-29immunoregulationintestinal barriermast cellsprobioticsSerobiomaTranswell co-culture model

Identifiers

PMID36835568
PMCPMC9963420
OpenAlexW4321377833

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.