Evidence map›Paper›PMID 36835538›Full record

ArticleInternational journal of molecular sciences2023

Application of Gold Nanoparticles as Radiosensitizer for Metastatic Prostate Cancer Cell Lines.

Sílvia Soares, Isabel Faria, Fátima Aires, Armanda Monteiro, Gabriela Pinto, Maria Goreti Sales, Miguel A Correa-Duarte, Susana G Guerreiro, Rúben Fernandes

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Microdosimetric Simulation of Gold-Nanoparticle-Enhanced Radiotherapy.International journal of molecular sciences · 2024
    Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Sílvia SoaresICBAS-School of Medicine and Biomedical Sciences, University of Porto, 4050-313 Porto, Portugal.ORCID 0000-0002-4344-7860
Isabel FariaSchool of Health, Polytechnic of Porto, 4200-072 Porto, Portugal.ORCID 0000-0002-1467-7800
Fátima AiresRadiotherapy Service, São João Hospital Center, 4200-319 Porto, Portugal.ORCID 0000-0001-8111-9123
Armanda MonteiroRadiotherapy Service, São João Hospital Center, 4200-319 Porto, Portugal.
Gabriela PintoRadiotherapy Service, São João Hospital Center, 4200-319 Porto, Portugal.
Maria Goreti SalesICBAS-School of Medicine and Biomedical Sciences, University of Porto, 4050-313 Porto, Portugal.ORCID 0000-0001-9936-7336
Miguel A Correa-DuarteCINBIO, University of Vigo, 36310 Vigo, Spain.ORCID 0000-0003-1950-1414
Susana G GuerreiroInstituto de Investigação e Inovação em Saúde (i3S), 4200-135 Porto, Portugal.ORCID 0000-0002-2432-2755
Rúben FernandesFP-I3ID, FP-BHS, Universidade Fernando Pessoa (UFP), 4249-004 Porto, Portugal.ORCID 0000-0001-8933-3984
Hospital de São João · PTFernando Pessoa University · PTUniversidade do Porto · PTCentro de Investigación Biomédica en Red de Salud Mental · ESPolytechnic Institute of Porto · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

More than 50% of all prostate cancer (PCa) patients are treated by radiotherapy (RT). Radioresistance and cancer recurrence are two consequences of the therapy and are related to dose heterogeneity and non-selectivity between normal and tumoral cells. Gold nanoparticles (AuNPs) could be used as potential radiosensitizers to overcome these therapeutic limitations of RT. This study assessed the biological interaction of different morphologies of AuNPs with ionizing radiation (IR) in PCa cells. To achieve that aim, three different amine-pegylated AuNPs were synthesized with distinct sizes and shapes (spherical, AuNP

Indexed as

Metal NanoparticlesProstatic NeoplasmsRadiation-Sensitizing AgentsCell Line, TumorGoldHumansMaleNeoplasm Recurrence, LocalGoldRadiation-Sensitizing Agentsgold nanoparticlesin vitro assayprostate cancerradiosensitizing effectradiotherapy

Identifiers

PMID36835538
PMCPMC9964626
OpenAlexW4321374088

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.