Evidence map›Paper›PMID 36835507›Full record

ArticleInternational journal of molecular sciences2023

Activation of Endothelial Large Conductance Potassium Channels Protects against TNF-α-Induced Inflammation.

Tatiana Zyrianova, Kathlyn Zou, Benjamin Lopez, Andy Liao, Charles Gu, Riccardo Olcese, Andreas Schwingshackl

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Effect of aortic smooth muscle BK channels on mediating chronic intermittent hypoxia-induced vascular dysfunction.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2024
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Tatiana ZyrianovaDepartments of Pediatrics, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-4295-6708
Kathlyn ZouDepartments of Pediatrics, University of California Los Angeles, Los Angeles, CA 90095, USA.
Benjamin LopezDepartments of Pediatrics, University of California Los Angeles, Los Angeles, CA 90095, USA.
Andy LiaoDepartments of Pediatrics, University of California Los Angeles, Los Angeles, CA 90095, USA.
Charles GuDepartments of Pediatrics, University of California Los Angeles, Los Angeles, CA 90095, USA.
Riccardo OlceseDepartments of Anesthesiology and Perioperative Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Andreas SchwingshacklDepartments of Pediatrics, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-5608-0199
University of California, Los Angeles · US

Funding

Trek-1 Potassium Channels Protect from Hyperoxia-induced Acute Lung InjuryR01HL146821 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SCHWINGSHACKL, ANDREAS · 2020 to 2024
$2.8M
The Role of TREK-1 potassium channels in ARDSR01HL175464 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Andreas Schwingshackl · 2024 to 2026
$2.3M
The Late L-type Ca Current as the Target for a New Class of AntiarrhythmicsR01HL134346 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OLCESE, RICCARDO · 2017 to 2020
$2.3M
The Role of 2-Pore Domain Potassium Channels in Acute Lung Injury.K08HL118118 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SCHWINGSHACKL, ANDREAS · 2014 to 2018
$792k
NHLBI NIH HHS K08 HL118118NHLBI NIH HHS R01 HL134346NHLBI NIH HHS R01 HL146821NHLBI NIH HHS R01 HL175464NIH HHS 4-441370-AS-29376NIH HHS R01HL134346 (R.O.)
6 · The paper itself

Abstract

Elevated TNF-α levels in serum and broncho-alveolar lavage fluid of acute lung injury patients correlate with mortality rates. We hypothesized that pharmacological plasma membrane potential (Em) hyperpolarization protects against TNF-α-induced CCL-2 and IL-6 secretion from human pulmonary endothelial cells through inhibition of inflammatory Ca

Indexed as

Alveolar Epithelial CellsChemokine CCL2Large-Conductance Calcium-Activated Potassium ChannelsPneumoniaTumor Necrosis Factor-alphaCalcium Channel BlockersHumansNifedipineCalcium Channel BlockersChemokine CCL2Large-Conductance Calcium-Activated Potassium ChannelsNifedipineTumor Necrosis Factor-alphaCCL-2endothelial cellsIL-6large conductance K+ channelsL-type voltage-gated Ca2+ channelslung inflammationNifedipineNS1619pathway analysisTNF-α

Identifiers

PMID36835507
PMCPMC9961193
OpenAlexW4321374419

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.