ReviewInternational journal of molecular sciences2023
Inhibition of Succinate Dehydrogenase by Pesticides (SDHIs) and Energy Metabolism.
Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- Design, synthesis and antifungal evaluation of novel indoline-containing pyrazole-4-carboxamide derivatives as potential succinate dehydrogenase inhibitors.Pest management science · 2026Article
- Metabolic regulation of calcium homeostasis via SERCA succination.Science advances · 2026Article
- Green Synthesis, In Silico Molecular Docking, and Evaluation of Pyrazole Derivatives for Their Antifungal and Antinemic Activity.Chemistry & biodiversity · 2026Article
- Seaweeds From the Veracruz Rocky Shore (Mexico) as Novel Sources of Bioactive Compounds Against Fusarium Species Pathogenic to Corn (Zea mays).Chemistry & biodiversity · 2026Article
- The hazards of metal exposure mediated by crops to human health from perspective of environmental health and control strategies.iScience · 2026Review
- Reviewing the thoroughness of human safety testing for succinate dehydrogenase inhibitors: fluopyram as a case study.Archives of toxicology · 2026Review
- Yeast community associated with winter wheat leaves and its sensitivity to fungicides.Scientific reports · 2026Article
- Fluopyram in agricultural ecosystems: environmental fate, microbial transformation, ecotoxicity, and resistance risks of an SDHI fungicide.Frontiers in microbiology · 2026Review
- The effects of the heavy metals cadmium and lead on six metabolic and immune-related enzymes in the loachPeerJ · 2026Article
- The Role of Mitochondrial Complexes in Liver Diseases.Journal of clinical and translational hepatology · 2025Review
- Barbigerone attenuates 3-nitropropionic acid-induced Huntington's disease-like neuropathology in rats via antioxidant, anti-inflammatory, and neuroprotective mechanisms.Scientific reports · 2025Article
- Active control of mitochondrial network morphology by metabolism-driven redox state.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Identification of a pathogenic SDHD mutation in a Chinese family with hereditary head and neck paraganglioma: implications for genetic counseling and management.World journal of surgical oncology · 2025Article
- Unveiling the molecular basis of paracetamol-induced hepatotoxicity: Interaction ofBiochemistry and biophysics reports · 2024Article
- Heterogeneous distribution of mitochondria and succinate dehydrogenase activity in human airway smooth muscle cells.FASEB bioAdvances · 2024Article
- Transcriptome Analysis ofMicroorganisms · 2024Article
- A new acyl derivative of sulfadimethoxine inhibits phagocyte oxidative burst and ameliorates inflammation in a mice model of zymosan-induced generalised inflammation.Inflammopharmacology · 2023Article
- Brainstem Modulates Parkinsonism-Induced Orofacial Sensorimotor Dysfunctions.International journal of molecular sciences · 2023Article
- The Epithelial to Mesenchymal Transition in Colorectal Cancer Progression: The Emerging Role of Succinate Dehydrogenase Alterations and Succinate Accumulation.Biomedicines · 2023Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Succinate dehydrogenase (SDH) is one of the enzymes of the tricarboxylic acid cycle (Krebs cycle) and complex II of the mitochondrial respiratory chain. A class of fungicides (SDHIs) targets the complex II reaction in the SDH. A large number of those in use have been shown to inhibit SDH in other phyla, including humans. This raises questions about possible effects on human health and non-target organisms in the environment. The present document will address metabolic consequences in mammals; it is neither a review on SDH nor is it about the toxicology of SDHIs. Most clinically relevant observations are linked to a severe decrease in SDH activity. Here we shall examine the mechanisms for compensating a loss of SDH activity and their possible weaknesses or adverse consequences. It can be expected that a mild inhibition of SDH will be compensated by the kinetic properties of this enzyme, but this implies a proportionate increase in succinate concentration. This would be relevant for succinate signaling and epigenetics (not reviewed here). With regard to metabolism, exposure of the liver to SDHIs would increase the risk for non-alcoholic fatty liver disease (NAFLD). Higher levels of inhibition may be compensated by modification of metabolic fluxes with net production of succinate. SDHIs are much more soluble in lipids than in water; consequently, a different diet composition between laboratory animals and humans is expected to influence their absorption.
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