Evidence map›Paper›PMID 36835444›Full record

ArticleInternational journal of molecular sciences2023

Untargeted Metabolomics Identifies Potential Hypertrophic Cardiomyopathy Biomarkers in Carriers of

Mark Jansen, Maike Schuldt, Beau O van Driel, Amand F Schmidt, Imke Christiaans, Saskia N van der Crabben, Yvonne M Hoedemaekers, Dennis Dooijes, Jan D H Jongbloed, Ludolf G Boven and 8 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. An Update on MYBPC3 Gene Mutation in Hypertrophic Cardiomyopathy.International journal of molecular sciences · 2023
    Review
  13. Molecular Mechanisms of Cardiac Development and Disease.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

Mark JansenDepartment of Genetics, University Medical Centre Utrecht, Utrecht University, 3584CX Utrecht, The Netherlands.ORCID 0000-0002-0896-4440
Maike SchuldtDepartment of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, 1081HZ Amsterdam, The Netherlands.ORCID 0000-0001-9401-6190
Beau O van DrielDepartment of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, 1081HZ Amsterdam, The Netherlands.ORCID 0000-0002-8287-3707
Amand F SchmidtDepartment of Cardiology, University Medical Centre Utrecht, Utrecht University, 3584CX Utrecht, The Netherlands.
Imke ChristiaansDepartment of Genetics, University Medical Centre Groningen, University of Groningen, 9713GZ Groningen, The Netherlands.
Saskia N van der CrabbenDepartment of Human Genetics, Amsterdam UMC, University of Amsterdam, 1105AZ Amsterdam, The Netherlands.
Yvonne M HoedemaekersDepartment of Clinical Genetics, Radboud University Medical Centre, 6525GA Nijmegen, The Netherlands.
Dennis DooijesDepartment of Genetics, University Medical Centre Utrecht, Utrecht University, 3584CX Utrecht, The Netherlands.
Jan D H JongbloedDepartment of Genetics, University Medical Centre Groningen, University of Groningen, 9713GZ Groningen, The Netherlands.ORCID 0000-0003-0663-404X
Ludolf G BovenDepartment of Genetics, University Medical Centre Groningen, University of Groningen, 9713GZ Groningen, The Netherlands.
Ronald H Lekanne DeprezDepartment of Human Genetics, Amsterdam UMC, University of Amsterdam, 1105AZ Amsterdam, The Netherlands.ORCID 0000-0003-4687-0186
Arthur A M WildeHeart Centre, Department of Cardiology, Amsterdam UMC, University of Amsterdam, 1081HZ Amsterdam, The Netherlands.
Judith J M JansDepartment of Genetics, University Medical Centre Utrecht, Utrecht University, 3584CX Utrecht, The Netherlands.ORCID 0000-0003-0960-6263
Jolanda van der VeldenDepartment of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, 1081HZ Amsterdam, The Netherlands.ORCID 0000-0001-5224-5788
Rudolf A de BoerDepartment of Cardiology, University Medical Centre Groningen, University of Groningen, 9713GZ Groningen, The Netherlands.
J Peter van TintelenDepartment of Genetics, University Medical Centre Utrecht, Utrecht University, 3584CX Utrecht, The Netherlands.ORCID 0000-0003-3854-6749
Folkert W AsselbergsNetherlands Heart Institute, 3511EP Utrecht, The Netherlands.ORCID 0000-0002-1692-8669
Annette F BaasDepartment of Genetics, University Medical Centre Utrecht, Utrecht University, 3584CX Utrecht, The Netherlands.
Utrecht University · NLAmsterdam University Medical Centers · NLUniversity Medical Center Groningen · NLRadboud University Nijmegen · NL

Funding

Hartstichting CVON2014-40; CVON2015-12; CVON2018-30 PREDICT2; CVON2020B005; Dekker 2015T041; 95105003Netherlands Organisation for Health Research and Development VICI 91818602; 95105003UCL Hospitals NIHR Biomedical Research Centre NA
6 · The paper itself

Abstract

Hypertrophic cardiomyopathy (HCM) is the most prevalent monogenic heart disease, commonly caused by pathogenic

Indexed as

Cardiomyopathy, HypertrophicFounder EffectMyosinsBiomarkersCase-Control StudiesCytoskeletal ProteinsHeterozygoteHumansMaleMutationMyosin Binding Protein CPhenotypeStroke VolumeVentricular Function, LeftBiomarkersCytoskeletal ProteinsMyosin Binding Protein CMyosinsbiomarkershypertrophic cardiomyopathymetabolomicsMYBPC3

Identifiers

PMID36835444
PMCPMC9961357
OpenAlexW4321243492

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.