Evidence map›Paper›PMID 36835299›Full record

ReviewInternational journal of molecular sciences2023

Allergy in Cancer Care: Antineoplastic Therapy-Induced Hypersensitivity Reactions.

Bianca Galateanu, Alexandra Ioana Pușcașu, Simona Andreea Tircol, Bogdan Cosmin Tanase, Ariana Hudita, Carolina Negrei, George-Traian-Alexandru Burcea-Dragomiroiu, Lucian Negreanu, Ileana Adela Vacaroiu, Octav Ginghină

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Trial
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  6. Review
  7. Article
  8. Identification of Novel β-Tubulin Inhibitors Using a CombinedJournal of chemical information and modeling · 2023
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Bianca GalateanuDepartment of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania.ORCID 0000-0001-8093-1750
Alexandra Ioana PușcașuFundeni Clinical Institute, 022328 Bucharest, Romania.
Simona Andreea TircolDepartment of Internal Medicine (Gastroenterology), Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Bogdan Cosmin TanaseInstitute of Oncology Prof. Dr. A. Trestioreanu Bucharest, 022328 Bucharest, Romania.
Ariana HuditaDepartment of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania.ORCID 0000-0002-9439-9432
Carolina NegreiDepartament of Toxicology, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
George-Traian-Alexandru Burcea-DragomiroiuDepartment of Drug Control, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.ORCID 0000-0001-9648-2953
Lucian NegreanuDepartment of Internal Medicine (Gastroenterology), Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0000-0003-3042-0754
Ileana Adela Vacaroiu"Sf. Ioan" Emergency Clinical Hospital, 042122 Bucharest, Romania.
Octav GinghinăDepartment of Drug Control, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Carol Davila University of Medicine and Pharmacy · ROUniversity of Bucharest · ROInstitutul Clinic Fundeni · ROInstitutul Oncologic Bucuresti · RO

Funding

Unitatea Executiva Pentru Finantarea Invatamantului Superior a Cercetarii Dezvoltarii si Inovarii PN-III-P1-1.1-TE-2021-1236
6 · The paper itself

Abstract

As the backbone of oncological treatments, systemic chemotherapy is still one of the main pawns in cancer care, alone or in combination with newer targeted agents. All chemotherapy agents can be associated with a type of adverse event called an infusion reaction, which can be characterized as unpredictable, non-dose related, and unexplained by the cytotoxic profile of the drug. For some of these events, a certain immunological mechanism can be identified by blood or skin testing. In this case, we can speak of true hypersensitivity reactions that occur as a response to an antigen/allergen. The current work summarizes the main antineoplastic therapy agents and their susceptibility to induce hypersensitivity reactions and also includes a review of clinical presentation, diagnostic methods in hypersensitivity reactions, and perspectives to overcome these negative events in the treatment of patients suffering from various types of cancer.

Indexed as

Antineoplastic AgentsDrug HypersensitivityHypersensitivityNeoplasmsHumansAntineoplastic Agentsantineoplastic therapycancerchemotherapyinfusion reactiononcology

Identifiers

PMID36835299
PMCPMC9961679
OpenAlexW4320918369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.