Evidence map›Paper›PMID 36835295›Full record

ReviewInternational journal of molecular sciences2023

Adipose-Derived Mesenchymal Stromal Cells in Basic Research and Clinical Applications.

Katarzyna Czerwiec, Małgorzata Zawrzykraj, Milena Deptuła, Aneta Skoniecka, Agata Tymińska, Jacek Zieliński, Adam Kosiński, Michał Pikuła

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katarzyna CzerwiecDivision of Clinical Anatomy, Department of Anatomy, Faculty of Medicine, Medical University of Gdansk, 80-211 Gdańsk, Poland.
Małgorzata ZawrzykrajDivision of Clinical Anatomy, Department of Anatomy, Faculty of Medicine, Medical University of Gdansk, 80-211 Gdańsk, Poland.ORCID 0000-0003-3144-6171
Milena DeptułaLaboratory of Tissue Engineering and Regenerative Medicine, Division of Embryology, Department of Anatomy, Faculty of Medicine, Medical University of Gdansk, 80-211 Gdańsk, Poland.ORCID 0000-0003-4875-770X
Aneta SkonieckaLaboratory of Tissue Engineering and Regenerative Medicine, Division of Embryology, Department of Anatomy, Faculty of Medicine, Medical University of Gdansk, 80-211 Gdańsk, Poland.
Agata TymińskaLaboratory of Tissue Engineering and Regenerative Medicine, Division of Embryology, Department of Anatomy, Faculty of Medicine, Medical University of Gdansk, 80-211 Gdańsk, Poland.ORCID 0000-0002-6195-1024
Jacek ZielińskiDepartment of Oncologic Surgery, Medical University of Gdansk, 80-214 Gdańsk, Poland.
Adam KosińskiDivision of Clinical Anatomy, Department of Anatomy, Faculty of Medicine, Medical University of Gdansk, 80-211 Gdańsk, Poland.
Michał PikułaLaboratory of Tissue Engineering and Regenerative Medicine, Division of Embryology, Department of Anatomy, Faculty of Medicine, Medical University of Gdansk, 80-211 Gdańsk, Poland.ORCID 0000-0001-7751-9781

Funding

National Science Centre - Poland 2019/33/B/NZ7/02676 granted to MP
6 · The paper itself

Abstract

Adipose-derived mesenchymal stromal cells (AD-MSCs) have been extensively studied in recent years. Their attractiveness is due to the ease of obtaining clinical material (fat tissue, lipoaspirate) and the relatively large number of AD-MSCs present in adipose tissue. In addition, AD-MSCs possess a high regenerative potential and immunomodulatory activities. Therefore, AD-MSCs have great potential in stem cell-based therapies in wound healing as well as in orthopedic, cardiovascular, or autoimmune diseases. There are many ongoing clinical trials on AD-MSC and in many cases their effectiveness has been proven. In this article, we present current knowledge about AD-MSCs based on our experience and other authors. We also demonstrate the application of AD-MSCs in selected pre-clinical models and clinical studies. Adipose-derived stromal cells can also be the pillar of the next generation of stem cells that will be chemically or genetically modified. Despite much research on these cells, there are still important and interesting areas to explore.

Indexed as

Mesenchymal Stem CellsMesenchymal Stem Cell TransplantationAdipose TissueCell DifferentiationAD-MSCsfat tissueregenerative medicinestem cells

Identifiers

PMID36835295
PMCPMC9962639

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.