Evidence map›Paper›PMID 36835270›Full record

ArticleInternational journal of molecular sciences2023

Moxonidine Increases Uptake of Oxidised Low-Density Lipoprotein in Cultured Vascular Smooth Muscle Cells and Inhibits Atherosclerosis in Apolipoprotein E-Deficient Mice.

Yutang Wang, Dinh Tam Nguyen, Jack Anesi, Ahmed Alramahi, Paul K Witting, Zhonglin Chai, Abdul Waheed Khan, Jason Kelly, Kate M Denton, Jonathan Golledge

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Triglycerides, Glucose Metabolism, and Type 2 Diabetes.International journal of molecular sciences · 2025
    Review
  2. Dexmedetomidine Reduces Chronic Stress-Related Thrombosis in a Mouse FeClFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  3. Review
  4. Special Issue "Sympathetic Nerves and Cardiovascular Diseases".International journal of molecular sciences · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Sympathetic Nervous System and Atherosclerosis.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Yutang WangDiscipline of Life Science, Institute of Innovation, Science and Sustainability, Federation University Australia, Ballarat, VIC 3350, Australia.ORCID 0000-0002-6264-6443
Dinh Tam NguyenDiscipline of Life Science, Institute of Innovation, Science and Sustainability, Federation University Australia, Ballarat, VIC 3350, Australia.
Jack AnesiDiscipline of Life Science, Institute of Innovation, Science and Sustainability, Federation University Australia, Ballarat, VIC 3350, Australia.
Ahmed AlramahiDiscipline of Life Science, Institute of Innovation, Science and Sustainability, Federation University Australia, Ballarat, VIC 3350, Australia.
Paul K WittingMolecular Biomedicine Theme, School of Medical Sciences, Faculty of Medicine and Health, Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0003-2237-7004
Zhonglin ChaiDepartment of Diabetes, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia.ORCID 0000-0001-8182-8579
Abdul Waheed KhanDepartment of Diabetes, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia.
Jason KellyFiona Elsey Cancer Research Institute, Ballarat, VIC 3350, Australia.ORCID 0000-0001-8223-2603
Kate M DentonDepartment of Physiology, Monash University, Melbourne, VIC 3800, Australia.ORCID 0000-0002-5929-4387
Jonathan GolledgeQueensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, QLD 4811, Australia.ORCID 0000-0002-5779-8848
Federation University · AUMonash University · AUThe University of Sydney · AUTownsville Hospital · AU

Funding

National Health and Medical Research Council of Australia 1062671
6 · The paper itself

Abstract

This study aimed to investigate the effect of the sympatholytic drug moxonidine on atherosclerosis. The effects of moxonidine on oxidised low-density lipoprotein (LDL) uptake, inflammatory gene expression and cellular migration were investigated in vitro in cultured vascular smooth muscle cells (VSMCs). The effect of moxonidine on atherosclerosis was measured by examining aortic arch Sudan IV staining and quantifying the intima-to-media ratio of the left common carotid artery in apolipoprotein E-deficient (ApoE

Indexed as

AtherosclerosisImidazolesLipoproteins, LDLMuscle, Smooth, VascularAnimalsApolipoproteins ECell ProliferationCells, CulturedLipid PeroxidesMiceMice, Inbred C57BLMyocytes, Smooth MuscleApolipoproteins EImidazolesLipid PeroxidesLipoproteins, LDLmoxonidineoxidized low density lipoproteinatherosclerosiscell migrationinflammationmoxonidine

Identifiers

PMID36835270
PMCPMC9960795
OpenAlexW4320920377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.