Loco-Regional Control and Sustained Difference in Serum Immune Protein Expression in Patients Treated for p16-Positive and p16-Negative Head and Neck Squamous Cell Carcinoma.

Karl Sandström, Ylva Tiblom Ehrsson, Felix Sellberg, Hemming Johansson, Göran Laurell

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.5field-weighted citation impact, top 28% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Karl SandströmDepartment of Surgical Sciences, Uppsala University, 751 85 Uppsala, Sweden.ORCID 0000-0001-7345-0916

Ylva Tiblom EhrssonDepartment of Surgical Sciences, Uppsala University, 751 85 Uppsala, Sweden.ORCID 0000-0001-7435-167X

Felix SellbergDepartment of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden.ORCID 0000-0002-9742-244X

Hemming JohanssonDepartment of Oncology-Pathology, Karolinska University Hospital, 171 76 Stockholm, Sweden.

Göran LaurellDepartment of Surgical Sciences, Uppsala University, 751 85 Uppsala, Sweden.

Uppsala University · SEKarolinska University Hospital · SE

Funding

Kamprad Family Foundation 20150003Regional Research Council in Uppsala-Örebro Region 561121Swedish Cancer Society 2015/363

6 · The paper itself

Abstract

The main prognostic factors for patients with head and neck cancer are the tumour site and stage, yet immunological and metabolic factors are certainly important, although knowledge is still limited. Expression of the biomarker p16INK4a (p16) in oropharyngeal cancer tumour tissue is one of the few biomarkers for the diagnosis and prognosis of head and neck cancer. The association between p16 expression in the tumour and the systemic immune response in the blood compartment has not been established. This study aimed to assess whether there is a difference in serum immune protein expression profiles between patients with p16+ and p16- head and squamous cell carcinoma (HNCC). The serum immune protein expression profiles, using the Olink

Indexed as

Cyclin-Dependent Kinase Inhibitor p16Oropharyngeal NeoplasmsSquamous Cell Carcinoma of Head and NeckBiomarkers, TumorHumansBiomarkers, TumorCyclin-Dependent Kinase Inhibitor p16cytokineshead and neck cancerP16protein expressionserum

Identifiers

PMID36835246

DOI10.3390/ijms24043838

PMCPMC9961007

OpenAlexW4320920207

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.