Evidence map›Paper›PMID 36835104›Full record

ArticleInternational journal of molecular sciences2023

Polyphenols with Anti-Inflammatory Properties: Synthesis and Biological Activity of Novel Curcumin Derivatives.

Yisett González, Randy Mojica-Flores, Dilan Moreno-Labrador, Luis Cubilla-Rios, K S Jagannatha Rao, Patricia L Fernández, Oleg V Larionov, Johant Lakey-Beitia

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Synthetic Cyclic CAntioxidants (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Article
  4. Synthetic Cyclic CAntioxidants (Basel, Switzerland) · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yisett GonzálezCenter for Molecular and Cellular Biology of Diseases, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Clayton, City of Knowledge, Panama City 0843-01103, Panama.ORCID 0000-0002-1623-9484
Randy Mojica-FloresCenter for Biodiversity and Drug Discovery, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Clayton, City of Knowledge, Panama City 0843-01103, Panama.ORCID 0000-0003-4514-3083
Dilan Moreno-LabradorCenter for Molecular and Cellular Biology of Diseases, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Clayton, City of Knowledge, Panama City 0843-01103, Panama.ORCID 0000-0001-9233-8583
Luis Cubilla-RiosSistema Nacional de Investigación (SNI), SENACYT, Panama City 0816-02852, Panama.ORCID 0000-0003-1666-8948
K S Jagannatha RaoCenter for Neuroscience, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Clayton, City of Knowledge, Panama City 0843-01103, Panama.ORCID 0000-0002-4801-3535
Patricia L FernándezCenter for Molecular and Cellular Biology of Diseases, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Clayton, City of Knowledge, Panama City 0843-01103, Panama.ORCID 0000-0002-0762-0566
Oleg V LarionovDepartment of Chemistry, The University of Texas at San Antonio, San Antonio, TX 78249, USA.
Johant Lakey-BeitiaSistema Nacional de Investigación (SNI), SENACYT, Panama City 0816-02852, Panama.ORCID 0000-0001-7554-4043

Funding

Instituto de Investigaciones Científicas y Servicios de Alta Tecnología JR04-2020Secretaría Nacional de Ciencia, Tecnología e Innovación FID17-002Secretaría Nacional de Ciencia, Tecnología e Innovación ITE18-R1-006
6 · The paper itself

Abstract

Herein, we describe the synthesis and evaluation of anti-inflammatory activities of new curcumin derivatives. The thirteen curcumin derivatives were synthesized by Steglich esterification on one or both of the phenolic rings of curcumin with the aim of providing improved anti-inflammatory activity. Monofunctionalized compounds showed better bioactivity than the difunctionalized derivatives in terms of inhibiting IL-6 production, and known compound

Indexed as

Anti-Inflammatory AgentsCurcuminPolyphenolsInterleukin-6Structure-Activity RelationshipAnti-Inflammatory AgentsCurcuminInterleukin-6Polyphenolsanti-inflammatory activitycurcumincurcumin derivativescytokinedifunctionalizedIL-6monofunctionalizedPGE2structure–activity relationshipsuccinate

Identifiers

PMID36835104
PMCPMC9966181

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.