Evidence map›Paper›PMID 36835088›Full record

ArticleInternational journal of molecular sciences2023

Acss2 Deletion Reveals Functional Versatility via Tissue-Specific Roles in Transcriptional Regulation.

Narayanan Puthillathu Vasudevan, Dharmendra K Soni, John R Moffett, Jishnu K S Krishnan, Abhilash P Appu, Sarani Ghoshal, Peethambaran Arun, John M Denu, Thomas P Flagg, Roopa Biswas and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Narayanan Puthillathu VasudevanDepartment of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Dharmendra K SoniDepartment of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0000-0002-7702-6546
John R MoffettDepartment of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0000-0002-2804-4553
Jishnu K S KrishnanDepartment of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0000-0001-9916-247X
Abhilash P AppuDepartment of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Sarani GhoshalDepartment of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Peethambaran ArunDepartment of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
John M DenuDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Thomas P FlaggDepartment of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0000-0002-3147-4060
Roopa BiswasDepartment of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.ORCID 0000-0003-1400-6692
Aryan M NamboodiriDepartment of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Uniformed Services University of the Health Sciences · USUniversity of Wisconsin–Madison · US

Funding

Molecular mechanisms of histone modification - Alzheimer’s supplement NOT-AG-18-008R37GM059785 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI DENU, JOHN M · 2013 to 2022
$3.7M
Dynamics and molecular mechanisms linking metabolism and the epigenomeR35GM149279 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI JOHN M DENU · 2023 to 2026
$2.8M
Acetate Supplementation as a therapeutic strategy for Canavan diseaseR21NS084206 · NINDS · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI NAMBOODIRI, ARYAN MANGALAM · 2014 to 2015
$418k
NIGMS NIH HHS R35 GM149279NIGMS NIH HHS R37 GM059785NIH HHS NS 084206NINDS NIH HHS R21 NS084206
6 · The paper itself

Abstract

The coordination of cellular biological processes is regulated in part via metabolic enzymes acting to match cellular metabolism to current conditions. The acetate activating enzyme, acyl-coenzyme A synthetase short-chain family member 2 (Acss2), has long been considered to have a predominantly lipogenic function. More recent evidence suggests that this enzyme has regulatory functions in addition to its role in providing acetyl-CoA for lipid synthesis. We used Acss2 knockout mice (

Indexed as

Acetate-CoA LigaseGene Expression RegulationAcetatesAnimalsFatty AcidsLipogenesisLiverMiceAcetate-CoA LigaseAcetatesACSS2 protein, mouseFatty Acidsacetateacetylationacetyl-CoA synthetaseacetyl-coenzyme AATP citrate lyasetranscriptional regulation

Identifiers

PMID36835088
PMCPMC9964712
OpenAlexW4320493135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.