Evidence map›Paper›PMID 36835023›Full record

ArticleInternational journal of molecular sciences2023

Towards Arginase Inhibition: Hybrid SAR Protocol for Property Mapping of Chlorinated

Andrzej Bak, Jiri Kos, Gilles Degotte, Aleksandra Swietlicka, Tomas Strharsky, Dominika Pindjakova, Tomas Gonec, Adam Smolinski, Pierre Francotte, Michel Frederich and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 5 countries.

Andrzej BakInstitute of Chemistry, University of Silesia, Szkolna 9, 40-007 Katowice, Poland.ORCID 0000-0002-9842-1289
Jiri KosDepartment of Biochemistry, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.ORCID 0000-0002-3589-4361
Gilles DegotteI2BM, Department of Molecular Chemistry, University Grenoble-Alpes, Rue de la Chimie 570, 38610 Gieres, France.
Aleksandra SwietlickaInstitute of Chemistry, University of Silesia, Szkolna 9, 40-007 Katowice, Poland.
Tomas StrharskyDepartment of Chemical Drugs, Faculty of Pharmacy, Masaryk University, Palackeho 1946/1, 612 00 Brno, Czech Republic.ORCID 0000-0001-9291-5424
Dominika PindjakovaDepartment of Analytical Chemistry, Faculty of Natural Sciences, Comenius University, Ilkovicova 6, 842 15 Bratislava, Slovakia.
Tomas GonecDepartment of Chemical Drugs, Faculty of Pharmacy, Masaryk University, Palackeho 1946/1, 612 00 Brno, Czech Republic.ORCID 0000-0003-3712-8641
Adam SmolinskiGiG Research Institute, Pl. Gwarkow 1, 40-166 Katowice, Poland.ORCID 0000-0002-4901-7546
Pierre FrancotteLaboratory of Medicinal Chemistry, CIRM, Department of Pharmacy, University of Liege, Avenue Hippocrate 15, 4000 Liege, Belgium.
Michel FrederichLaboratory of Pharmacognosy, CIRM, Department of Pharmacy, University of Liege, Avenue Hippocrate 15, 4000 Liege, Belgium.ORCID 0000-0002-0770-9990
Violetta KozikInstitute of Chemistry, University of Silesia, Szkolna 9, 40-007 Katowice, Poland.
Josef JampilekDepartment of Analytical Chemistry, Faculty of Natural Sciences, Comenius University, Ilkovicova 6, 842 15 Bratislava, Slovakia.ORCID 0000-0003-2003-9052
Masaryk University · CZUniversity of Silesia in Katowice · PLUniversity of Liège · BEComenius University Bratislava · SKSlovak Academy of Sciences · SKUniversité Grenoble Alpes · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of seventeen 4-chlorocinnamanilides and seventeen 3,4-dichlorocinnamanilides were characterized for their antiplasmodial activity. In vitro screening on a chloroquine-sensitive strain of

Indexed as

AntimalarialsArginaseChloroquineMolecular Docking SimulationPlasmodium falciparumStructure-Activity RelationshipAntimalarialsArginaseChloroquinearginase inhibitionarylcinnamamidesCoMSAlipophilicitymolecular dockingsimilarity-activity landscape index

Identifiers

PMID36835023
PMCPMC9968098
OpenAlexW4320496011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.