Evidence map›Paper›PMID 36835012›Full record

ArticleInternational journal of molecular sciences2023

Cell Uptake of Steroid-BODIPY Conjugates and Their Internalization Mechanisms: Cancer Theranostic Dyes.

Ana F Amendoeira, André Luz, Ruben Valente, Catarina Roma-Rodrigues, Hasrat Ali, Johan E van Lier, Fernanda Marques, Pedro V Baptista, Alexandra R Fernandes

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Ana F AmendoeiraAssociate Laboratory i4HB, Institute for Health and Bioeconomy, NOVA School of Science and Technology, 2819-516 Caparica, Portugal.
André LuzAssociate Laboratory i4HB, Institute for Health and Bioeconomy, NOVA School of Science and Technology, 2819-516 Caparica, Portugal.ORCID 0000-0001-7764-9033
Ruben ValenteAssociate Laboratory i4HB, Institute for Health and Bioeconomy, NOVA School of Science and Technology, 2819-516 Caparica, Portugal.ORCID 0000-0001-6534-4128
Catarina Roma-RodriguesAssociate Laboratory i4HB, Institute for Health and Bioeconomy, NOVA School of Science and Technology, 2819-516 Caparica, Portugal.ORCID 0000-0002-8676-6562
Hasrat AliDepartment of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC J1H5N4, Canada.
Johan E van LierDepartment of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC J1H5N4, Canada.ORCID 0000-0002-2190-4557
Fernanda MarquesCentro de Ciências e Tecnologias Nucleares, Departamento de Engenharia e Ciências Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10, km 139.7, 2695-066 Bobadela, Portugal.ORCID 0000-0001-8440-5299
Pedro V BaptistaAssociate Laboratory i4HB, Institute for Health and Bioeconomy, NOVA School of Science and Technology, 2819-516 Caparica, Portugal.ORCID 0000-0001-5255-7095
Alexandra R FernandesAssociate Laboratory i4HB, Institute for Health and Bioeconomy, NOVA School of Science and Technology, 2819-516 Caparica, Portugal.ORCID 0000-0003-2054-4438
Unidade em Ciências Biomoleculares AplicadasUniversité de Sherbrooke · CAUniversity of Lisbon · PT

Funding

Ministry of Science Technology and Higher Education UIDP/04378/2020; UIDB/04378/2020; LA/P/0140/2020; SFRH/BPD/124612/2016; SFRH/BPD/12161/2022; SFRH/BD/09845/2022
6 · The paper itself

Abstract

Estradiol-BODIPY linked via an 8-carbon spacer chain and 19-nortestosterone- and testosterone-BODIPY linked via an ethynyl spacer group were evaluated for cell uptake in the breast cancer cell lines MCF-7 and MDA-MB-231 and prostate cancer cell lines PC-3 and LNCaP, as well as in normal dermal fibroblasts, using fluorescence microscopy. The highest level of internalization was observed with 11β-OMe-estradiol-BODIPY

Indexed as

NandroloneNeoplasmsPhotochemotherapyBoron CompoundsCell Line, TumorColoring AgentsEstradiolFluorescent DyesPhotosensitizing AgentsPrecision Medicine4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneBoron CompoundsColoring AgentsEstradiolFluorescent DyesNandrolonePhotosensitizing Agentsandrogen-BODIPY conjugatesestradiol-BODIPY conjugatesfluorescence imagingphotodynamic therapyphotosensitizersreceptor-mediated cell uptake

Identifiers

PMID36835012
PMCPMC9963437
OpenAlexW4320493605

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.