Evidence map›Paper›PMID 36835001›Full record

ArticleInternational journal of molecular sciences2023

Radiosensitization of Breast Cancer Cells with a 2-Methoxyestradiol Analogue Affects DNA Damage and Repair Signaling In Vitro.

Elsie Magdalena Nolte, Anna Margaretha Joubert, Laurence Lafanechère, Anne Elisabeth Mercier

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Elsie Magdalena NolteDepartment of Physiology, University of Pretoria, Pretoria 0007, South Africa.ORCID 0000-0002-0435-7416
Anna Margaretha JoubertDepartment of Physiology, University of Pretoria, Pretoria 0007, South Africa.ORCID 0000-0002-6931-7554
Laurence LafanechèreDepartment of Physiology, University of Pretoria, Pretoria 0007, South Africa.ORCID 0000-0002-7902-7630
Anne Elisabeth MercierDepartment of Physiology, University of Pretoria, Pretoria 0007, South Africa.ORCID 0000-0002-2030-9879
University of Pretoria · ZACentre National de la Recherche Scientifique · FR

Funding

Cancer Association of South Africa AOW228, AOV741National Research Foundation N00591, 89337, N00733,AOX981, N00375Research Committee (School of Medicine) of the University of Pretoria AOR984South African Medical Research Council AOW110The Struwig-Germeshuysen Trust AON074
6 · The paper itself

Abstract

Radiation resistance and radiation-related side effects warrant research into alternative strategies in the application of this modality to cancer treatment. Designed in silico to improve the pharmacokinetics and anti-cancer properties of 2-methoxyestradiol, 2-ethyl-3-

Indexed as

Breast NeoplasmsDNA DamageDNA RepairEstrenes2-MethoxyestradiolApoptosisCell Line, TumorFemaleHumansSulfonamides2-ethyl-3-O-sulfamoylestra-1,3,5(10)16-tetraene2-MethoxyestradiolEstrenesSulfonamides2-methoxyestradiol analogueactinapoptosiscancerDNA damage and repairESE-16microtubule dynamicsradiationradiation-induced bystander effectradiosensitization

Identifiers

PMID36835001
PMCPMC9965329
OpenAlexW4320496390

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.