Evidence map›Paper›PMID 36834818›Full record

ArticleInternational journal of molecular sciences2023

CBL/CAP Is Essential for Mitochondria Respiration Complex I Assembly and Bioenergetics Efficiency in Muscle Cells.

Cho-Cho Aye, Dean E Hammond, Sergio Rodriguez-Cuenca, Mary K Doherty, Phillip D Whitfield, Marie M Phelan, Chenjing Yang, Rafael Perez-Perez, Xiaoxin Li, Angels Diaz-Ramos and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Extrachromosomal Circular DNA and Transposable Elements in Type 2 Diabetes.International journal of molecular sciences · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 4 countries.

Cho-Cho AyeThe Department of Cellular and Molecular Physiology, Institute of Translational Medicine, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK.
Dean E HammondThe Department of Cellular and Molecular Physiology, Institute of Translational Medicine, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK.
Sergio Rodriguez-CuencaMetabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0001-9635-0504
Mary K DohertyDivision of Biomedical Sciences, Centre for Health Science, University of the Highlands and Islands, Old Perth Road, Inverness IV2 3JH, UK.ORCID 0000-0002-3480-4088
Phillip D WhitfieldDivision of Biomedical Sciences, Centre for Health Science, University of the Highlands and Islands, Old Perth Road, Inverness IV2 3JH, UK.
Marie M PhelanCentre for Nuclear Magnetic Resonance, Institute of Integrative Biology, University of Liverpool, Crown Street, Liverpool L69 3BX, UK.
Chenjing YangThe Department of Cellular and Molecular Physiology, Institute of Translational Medicine, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK.
Rafael Perez-PerezInstituto de Investigación, Hospital Universitario 12 de Octubre, Avda. de Córdoba s/n, 28041 Madrid, Spain.
Xiaoxin LiThe Department of Cellular and Molecular Physiology, Institute of Translational Medicine, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK.
Angels Diaz-RamosInstitute for Research in Biomedicine, C/Baldiri Reixac 10, 08028 Barcelona, Spain.
Gopal PeddintiTechnical Research Centre of Finland, 02044 Espoo, Finland.ORCID 0000-0002-8767-968X
Matej OresicTechnical Research Centre of Finland, 02044 Espoo, Finland.
Antonio Vidal-PuigMetabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, UK.
Antonio ZorzanoInstitute for Research in Biomedicine, C/Baldiri Reixac 10, 08028 Barcelona, Spain.
Cristina UgaldeInstituto de Investigación, Hospital Universitario 12 de Octubre, Avda. de Córdoba s/n, 28041 Madrid, Spain.ORCID 0000-0002-9742-1877
Silvia MoraThe Department of Cellular and Molecular Physiology, Institute of Translational Medicine, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK.ORCID 0000-0002-8473-1497
University of Liverpool · GBHospital Universitario 12 De Octubre · ESUniversity of Cambridge · GBUniversity of the Highlands and Islands · GBÅbo Akademi University · FIInstitute for Research in Biomedicine · ESInstituto de Salud Carlos III · ESVTT Technical Research Centre of Finland · FI

Funding

The Biosynthetic Pathway of Mitochondrial RespirasomesR01GM105781 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BARRIENTOS, ANTONI · 2014 to 2016
$894k
British Heart Foundation RG/18/7/33636Medical Research Council MC_UU_00014/2Medical Research Council MC_UU_00014/5NIGMS NIH HHS R01 GM105781
6 · The paper itself

Abstract

CBL is rapidly phosphorylated upon insulin receptor activation. Mice whole body CBL depletion improved insulin sensitivity and glucose clearance; however, the precise mechanisms remain unknown. We depleted either CBL or its associated protein SORBS1/CAP independently in myocytes and assessed mitochondrial function and metabolism compared to control cells. CBL- and CAP-depleted cells showed increased mitochondrial mass with greater proton leak. Mitochondrial respiratory complex I activity and assembly into respirasomes were reduced. Proteome profiling revealed alterations in proteins involved in glycolysis and fatty acid degradation. Our findings demonstrate CBL/CAP pathway couples insulin signaling to efficient mitochondrial respiratory function and metabolism in muscle.

Indexed as

Insulin ResistanceProto-Oncogene Proteins c-cblAnimalsCell RespirationEnergy MetabolismInsulinMiceMicrofilament ProteinsMitochondriaMitochondria, MuscleMuscle CellsCbl protein, mouseInsulinMicrofilament ProteinsponsinProto-Oncogene Proteins c-cblCBLglucose transportinsulin resistanceinsulin signallingmitochondriaSORBS1

Identifiers

PMID36834818
PMCPMC9964740
OpenAlexW4319763426

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.