Evidence map›Paper›PMID 36834800›Full record

ArticleInternational journal of molecular sciences2023

Decreased Vitamin D Levels and Altered Placental Vitamin D Gene Expression at High Altitude: Role of Genetic Ancestry.

Eugenia Mata-Greenwood, Hans C A Westenburg, Stacy Zamudio, Nicholas P Illsley, Lubo Zhang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Eugenia Mata-GreenwoodLawrence D. Longo Center for Perinatal Biology, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA.
Hans C A WestenburgLawrence D. Longo Center for Perinatal Biology, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA.
Stacy ZamudioPlacental Research Group LLC, Maplewood, NJ 07040, USA.
Nicholas P IllsleyPlacental Research Group LLC, Maplewood, NJ 07040, USA.ORCID 0000-0002-4336-2832
Lubo ZhangLawrence D. Longo Center for Perinatal Biology, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA.ORCID 0000-0002-9386-8938
Loma Linda University · US

Funding

Uterine Vascular Adaptation to Pregnancy and Chronic HypoxiaP01HD083132 · NICHD · LOMA LINDA UNIVERSITY · PI DUCSAY, CHARLES A · 2016 to 2020
$6.3M
Gestational Hypoxia and Programming of Maternal, Fetal and Newborn Vascular FunctionR01HL149608 · NHLBI · LOMA LINDA UNIVERSITY · PI PEARCE, WILLIAM J., WILSON, SEAN M · 2020 to 2023
$3.1M
Altitude-induced hypoxia,IUGR and placental functionR01HD042737 · NICHD · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI ZAMUDIO, STACY · 2003 to 2006
$1.1M
DATA ANALYSIS AND STATISTICAL PROGRAMMING SUPPORTN01HD083276 · NICHD · ALLIED TECHNOLOGY GROUP, INC. · PI DAVIS, JANSEN N · 1998 to 2000
$937k
Dissociating hypoxia from pathology in preeclampsia and*R03TW007444 · FIC · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI ZAMUDIO, STACY · 2006 to 2007
$78k
FIC NIH HHS R03 TW007444FIC NIH HHS TW007444NHLBI NIH HHS R01 HL149608NICHD NIH HHS P01 HD083132NICHD NIH HHS R01 HD042737NIH HHS HD083132NIH HHS HD083276NIH HHS HD42737
6 · The paper itself

Abstract

High-altitude hypoxia challenges reproduction; particularly in non-native populations. Although high-altitude residence is associated with vitamin D deficiency, the homeostasis and metabolism of vitamin D in natives and migrants remain unknown. We report that high altitude (3600 m residence) negatively impacted vitamin D levels, with the high-altitude Andeans having the lowest 25-OH-D levels and the high-altitude Europeans having the lowest 1α,25-(OH)

Indexed as

Vitamin DVitamin D Deficiency25-Hydroxyvitamin D3 1-alpha-HydroxylaseAltitudeCytochrome P-450 Enzyme SystemFemaleGene ExpressionHumansLow Density Lipoprotein Receptor-Related Protein-2PlacentaPregnancyVitamin D3 24-HydroxylaseVitamins25-Hydroxyvitamin D3 1-alpha-HydroxylaseCytochrome P-450 Enzyme SystemLow Density Lipoprotein Receptor-Related Protein-2Vitamin DVitamin D3 24-HydroxylaseVitaminsgenetic ancestryhigh altitudemetabolismplacentavitamin D

Identifiers

PMID36834800
PMCPMC9967090
OpenAlexW4319598144

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.