Evidence map›Paper›PMID 36834771›Full record

ArticleInternational journal of molecular sciences2023

Nucleoside Analogs That Inhibit SARS-CoV-2 Replication by Blocking Interaction of Virus Polymerase with RNA.

Elena Matyugina, Ivan Petushkov, Sergei Surzhikov, Vasily Kezin, Anna Maslova, Olga Ivanova, Olga Smirnova, Ilya Kirillov, Irina Fedyakina, Andrey Kulbachinskiy and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Elena MatyuginaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.ORCID 0000-0002-4981-7316
Ivan PetushkovInstitute of Molecular Genetics, National Research Center "Kurchatov Institute", 123182 Moscow, Russia.
Sergei SurzhikovEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Vasily KezinEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Anna MaslovaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Olga IvanovaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.ORCID 0000-0002-3673-4714
Olga SmirnovaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Ilya KirillovGamaleya National Research Center for Epidemiology and Microbiology, Russian Ministry of Health, 123098 Moscow, Russia.
Irina FedyakinaGamaleya National Research Center for Epidemiology and Microbiology, Russian Ministry of Health, 123098 Moscow, Russia.
Andrey KulbachinskiyInstitute of Molecular Genetics, National Research Center "Kurchatov Institute", 123182 Moscow, Russia.
Sergey KochetkovEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Anastasia KhandazhinskayaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.ORCID 0000-0003-1452-0253
Engelhardt Institute of Molecular Biology · RUKurchatov Institute · RUMinistry of Health of the Russian Federation · RU

Funding

Ministry of Science and Higher Education of the Russian Federation "Analogues of nucleic acid components as potential inhibitors of coronaviruses"Russian Science Foundation 21-74-10146
6 · The paper itself

Abstract

The SARS-CoV-2 betacoronavirus pandemic has claimed more than 6.5 million lives and, despite the development and use of COVID-19 vaccines, remains a major global public health problem. The development of specific drugs for the treatment of this disease remains a very urgent task. In the context of a repurposing strategy, we previously screened a library of nucleoside analogs showing different types of biological activity against the SARS-CoV-2 virus. The screening revealed compounds capable of inhibiting the reproduction of SARS-CoV-2 with EC

Indexed as

COVID-19SARS-CoV-2Antiviral AgentsCOVID-19 VaccinesHumansNucleosidesRNA-Dependent RNA PolymeraseRNA, ViralVirus ReplicationAntiviral AgentsCOVID-19 VaccinesNucleosidesRNA-Dependent RNA PolymeraseRNA, Viral6-substituted derivatives of 3H-pyrrolo [2,3-d]-pyrimidine-2-oneantiviral activitycarbocyclic and acyclic analogs of nucleosidesinfluenza virusinhibitorsSARS-CoV-2 RNA-dependent RNA polymerase

Identifiers

PMID36834771
PMCPMC9959748
OpenAlexW4319600841

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.