Evidence map›Paper›PMID 36834739›Full record

ReviewInternational journal of molecular sciences2023

Brugada Syndrome: From Molecular Mechanisms and Genetics to Risk Stratification.

Irene Paula Popa, Dragomir N Șerban, Minela Aida Mărănducă, Ionela Lăcrămioara Șerban, Bogdan Ionel Tamba, Ionuț Tudorancea

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Brugada syndrome in the forensic field: what do we know to date?Frontiers in cardiovascular medicine · 2025
    Review
  6. Zebrafish as a Model System for Brugada Syndrome.Reviews in cardiovascular medicine · 2024
    Review
  7. Article
  8. Review
  9. Primary Electrical Heart Disease-Principles of Pathophysiology and Genetics.International journal of molecular sciences · 2024
    Review
  10. Brugada syndrome update.Frontiers in physiology · 2024
    Review
  11. Review
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Irene Paula PopaCardiology Clinic, "St. Spiridon" County Clinical Emergency Hospital, 700111 Iași, Romania.
Dragomir N ȘerbanDepartment of Physiology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.
Minela Aida MărănducăDepartment of Physiology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.ORCID 0000-0002-2736-9700
Ionela Lăcrămioara ȘerbanDepartment of Physiology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.
Bogdan Ionel TambaDepartment of Pharmacology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.ORCID 0000-0001-9868-1999
Ionuț TudoranceaCardiology Clinic, "St. Spiridon" County Clinical Emergency Hospital, 700111 Iași, Romania.ORCID 0000-0002-4956-2595
Grigore T. Popa University of Medicine and Pharmacy · ROSpitalul Clinic Judeţean de Urgenţe "Sf. Spiridon" Iaşi · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brugada syndrome (BrS) is a rare hereditary arrhythmia disorder, with a distinctive ECG pattern, correlated with an increased risk of ventricular arrhythmias and sudden cardiac death (SCD) in young adults. BrS is a complex entity in terms of mechanisms, genetics, diagnosis, arrhythmia risk stratification, and management. The main electrophysiological mechanism of BrS requires further research, with prevailing theories centered on aberrant repolarization, depolarization, and current-load match. Computational modelling, pre-clinical, and clinical research show that BrS molecular anomalies result in excitation wavelength (k) modifications, which eventually increase the risk of arrhythmia. Although a mutation in the

Indexed as

Brugada SyndromeArrhythmias, CardiacElectrocardiographyHumansMutationNAV1.5 Voltage-Gated Sodium ChannelRisk AssessmentRisk FactorsYoung AdultNAV1.5 Voltage-Gated Sodium ChannelarrhythmiasBrugada syndromegeneticsgenome-wide associationlocimolecular mechanismmutationsSCN5Asudden cardiac deathsusceptibility

Identifiers

PMID36834739
PMCPMC9967917
OpenAlexW4319600047

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.