Evidence map›Paper›PMID 36834676›Full record

ArticleInternational journal of molecular sciences2023

Effects of Fractionated Radiation Exposure on Vimentin Expression in Cervical Cancers: Analysis of Association with Cancer Stem Cell Response and Short-Term Prognosis.

Irina Zamulaeva, Olga Matchuk, Elena Selivanova, Liana Mkrtchian, Anna Yakimova, Victoria Gusarova, Nikita Lipunov, Liudmila Krikunova, Sergey Ivanov, Andrey Kaprin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Irina ZamulaevaDepartment of Radiation Biochemistry, A. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Korolev Str.-4, Obninsk 249036, Russia.ORCID 0000-0002-6136-8445
Olga MatchukDepartment of Radiation Biochemistry, A. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Korolev Str.-4, Obninsk 249036, Russia.
Elena SelivanovaDepartment of Radiation Biochemistry, A. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Korolev Str.-4, Obninsk 249036, Russia.
Liana MkrtchianDepartment of Radiation and Combined Treatment of Gynecological Diseases, A. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Korolev Str.-4, Obninsk 249036, Russia.
Anna YakimovaDepartment of Radiation Biochemistry, A. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Korolev Str.-4, Obninsk 249036, Russia.ORCID 0000-0002-7834-6533
Victoria GusarovaDepartment of Radiation Biochemistry, A. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Korolev Str.-4, Obninsk 249036, Russia.
Nikita LipunovDepartment of Radiation Biochemistry, A. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Korolev Str.-4, Obninsk 249036, Russia.
Liudmila KrikunovaDepartment of Radiation and Combined Treatment of Gynecological Diseases, A. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Korolev Str.-4, Obninsk 249036, Russia.
Sergey IvanovA. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Korolev Str.-4, Obninsk 249036, Russia.
Andrey KaprinDepartment of Urology and Operative Nephrology, RUDN University, Miklukho-Maklaya Str.-6, Moscow 117198, Russia.
Ministry of Health of the Russian Federation · RUPeoples' Friendship University of Russia · RU

Funding

Russian Science Foundation 18-75-10025
6 · The paper itself

Abstract

Elucidation of the mechanisms for the response of cancer stem cells (CSCs) to radiation exposure is of considerable interest for further improvement of radio- and chemoradiotherapy of cervical cancer (CC). The aim of this work is to evaluate the effects of fractionated radiation exposure on the expression of vimentin, which is one of the end-stage markers of epithelial-mesenchymal transition (EMT), and analyze its association with CSC radiation response and short-term prognosis of CC patients. The level of vimentin expression was determined in HeLa, SiHa cell lines, and scrapings from the cervix of 46 CC patients before treatment and after irradiation at a total dose of 10 Gy using real-time polymerase chain reaction (PCR) assay, flow cytometry, and fluorescence microscopy. The number of CSCs was assessed using flow cytometry. Significant correlations were shown between vimentin expression and postradiation changes in CSC numbers in both cell lines (R = 0.88,

Indexed as

Uterine Cervical NeoplasmsCell Line, TumorCell MovementEpithelial-Mesenchymal TransitionFemaleHeLa CellsHumansNeoplastic Stem CellsVimentinVimentinVIM protein, humancancer stem cellscervical cancerepithelial-mesenchymal transitionflow cytometryHeLaionizing radiationradiosensitivitySiHavimentin

Identifiers

PMID36834676
PMCPMC9960894
OpenAlexW4319600824

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.