Evidence map›Paper›PMID 36834668›Full record

ArticleInternational journal of molecular sciences2023

Quantitative Proteomics of Human Retinal Pigment Epithelium Reveals Key Regulators for the Pathogenesis of Age-Related Macular Degeneration.

Shichen Shen, Rebecca J Kapphahn, Ming Zhang, Shuo Qian, Sandra R Montezuma, Peng Shang, Deborah A Ferrington, Jun Qu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Shichen ShenDepartment of Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14214, USA.
Rebecca J KapphahnDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN 55455, USA.
Ming ZhangDepartment of Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14214, USA.
Shuo QianDepartment of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA.
Sandra R MontezumaDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN 55455, USA.
Peng ShangDoheny Eye Institute, Pasadena, CA 91103, USA.
Deborah A FerringtonDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN 55455, USA.
Jun QuDepartment of Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14214, USA.ORCID 0000-0002-1346-6809
University at Buffalo, State University of New York · USUniversity of Minnesota · USDoheny Eye Institute · USRoswell Park Comprehensive Cancer Center · US

Funding

Mitochondrial defects in the retinal pigment epithelium and the CFH risk allele for age-related macular degenerationR01EY028554 · NEI · UNIVERSITY OF MINNESOTA · PI DUTTON, JAMES R., FERRINGTON, DEBORAH ANN · 2018 to 2025
$4.5M
Age-related macular degeneration,mitochondria and the CFH genotypeR01EY026012 · NEI · UNIVERSITY OF MINNESOTA · PI FERRINGTON, DEBORAH ANN · 2016 to 2019
$1.7M
Deciphering the mechanisms associated with high-risk AMD genotypes for ARMS2/HTRA1 andComplement Factor HU01EY034669 · NEI · DOHENY EYE INSTITUTE · PI FERRINGTON, DEBORAH ANN · 2022 to 2024
$1.2M
NEI NIH HHS R01 EY026012NEI NIH HHS R01 EY028554NEI NIH HHS U01 EY034669NIH HHS EY026012NIH HHS EY028554NIH HHS EY034669
6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is the leading cause of blindness in elderly people, with limited treatment options available for most patients. AMD involves the death of retinal pigment epithelium (RPE) and photoreceptor cells, with mitochondria dysfunction being a critical early event. In the current study, we utilized our unique resource of human donor RPE graded for AMD presence and severity to investigate proteome-wide dysregulation involved in early AMD. Organelle-enriched fractions of RPE were isolated from donors with early AMD (

Indexed as

Macular DegenerationRetinal Pigment EpitheliumAgedHumansOxidative StressProteomicsReproducibility of Resultsage-related macular degenerationIonStarmass spectrometrymitochondria dysfunctionquantitative proteomicsretinal pigment epithelium

Identifiers

PMID36834668
PMCPMC9959910
OpenAlexW4319600909

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.